Sign in

NCT07774143Recruiting

A Prospective, Multicenter, Randomized Controlled Trial Investigating the Impact of Fasting Duration on Postoperative Rebleeding Following Esophageal Variceal Ligation.

Source: ClinicalTrials.gov · Last updated 19 Aug 2026

Brief summary (registry, in English)

To evaluate the efficacy and safety of early postoperative oral intake (with a fasting period of 6 hours) versus delayed postoperative oral intake (with fasting periods of 24 hours or 48 hours) in patients with cirrhosis undergoing esophageal variceal ligation therapy.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
339 (estimated)
First submitted
16 Aug 2026
Start date
20 Jun 2026
Primary completion date
1 Jun 2027
Lead sponsor
The First Affiliated Hospital of Zhengzhou University
NCT number
NCT07774143

What you commit to

  • Study type: Interventional
  • Planned participants: 339
  • From 20 Jun 2026 to the primary completion date, 1 Jun 2027
  • 12 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Lab values

  • 1\. Uncontrolled active bleeding or concurrent bleeding from gastric fundal varices; 2.History of prior TIPS, EVL, or surgical shunt procedures; 3. Presence of severe systemic diseases, such as sepsis, uremia, or advanced hepatocellular carcinoma (HCC); 4.Mechanical ventilation with retained catheter, inability to take oral intake, or significant dysphagia, or a history of major esophageal/gastric surgery that has impaired swallowing function; 5. Severe hepatic failure: Child-Pugh score\>13; profound jaundice (serum bilirubin\>10 mg/dL) accompanied by altered consciousness beyond Stage II or massive ascites; 6.Pregnancy or lactation; 7. Inability to provide informed consent.

Who the study is looking for

  • -1. The patient must be aged\>18 years; 2. The diagnosis of portal hypertension must be confirmed, with gastroscopy revealing severe esophageal varices and a positive red sign; 3. For patients undergoing endoscopic variceal ligation (EVL) due to esophageal varices (including those with hemorrhage or those eligible for elective ligation), successful intraoperative ligation is achieved (achieving hemostasis or completing the predetermined ligation procedure).
  • 4\. Sign the informed consent form

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (12)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
The Fifth People's Hospital of Anyang
Coordinator of this site? Confirm its status
AnyangChinaRecruiting
The Secend People's Hospital of Jiaozuo
Coordinator of this site? Confirm its status
JiaozuoChinaRecruiting
Huaihe Hospital of Henan University
Coordinator of this site? Confirm its status
KaifengChinaRecruiting
Luohe Central Hospital
Coordinator of this site? Confirm its status
LuoheChinaRecruiting
Luoyang Central Hospital
Coordinator of this site? Confirm its status
LuoyangChinaRecruiting
Nanyang Central Hospital
Coordinator of this site? Confirm its status
NanyangChinaRecruiting
Sanmenxia Central Hospital
Coordinator of this site? Confirm its status
SanmenxiaChinaRecruiting
Shangqiu Municipal Hospital
Coordinator of this site? Confirm its status
ShangqiuChinaRecruiting
The First Affiliated Hospital of Xinxiang Medical University
Coordinator of this site? Confirm its status
XinxiangChinaRecruiting
Xuchang Central Hospital
Coordinator of this site? Confirm its status
XuchangChinaRecruiting
The First Affiliated Hospital of Zhengzhou University
Coordinator of this site? Confirm its status
ZhengzhouChinaRecruiting
Zhoukou Central Hospital
Coordinator of this site? Confirm its status
ZhoukouChinaRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.