NCT07774143Recruiting
A Prospective, Multicenter, Randomized Controlled Trial Investigating the Impact of Fasting Duration on Postoperative Rebleeding Following Esophageal Variceal Ligation.
Source: ClinicalTrials.gov · Last updated 19 Aug 2026
Brief summary (registry, in English)
To evaluate the efficacy and safety of early postoperative oral intake (with a fasting period of 6 hours) versus delayed postoperative oral intake (with fasting periods of 24 hours or 48 hours) in patients with cirrhosis undergoing esophageal variceal ligation therapy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 339 (estimated)
- First submitted
- 16 Aug 2026
- Start date
- 20 Jun 2026
- Primary completion date
- 1 Jun 2027
- Lead sponsor
- The First Affiliated Hospital of Zhengzhou University
- NCT number
- NCT07774143
What you commit to
- Study type: Interventional
- Planned participants: 339
- From 20 Jun 2026 to the primary completion date, 1 Jun 2027
- 12 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- 1\. Uncontrolled active bleeding or concurrent bleeding from gastric fundal varices; 2.History of prior TIPS, EVL, or surgical shunt procedures; 3. Presence of severe systemic diseases, such as sepsis, uremia, or advanced hepatocellular carcinoma (HCC); 4.Mechanical ventilation with retained catheter, inability to take oral intake, or significant dysphagia, or a history of major esophageal/gastric surgery that has impaired swallowing function; 5. Severe hepatic failure: Child-Pugh score\>13; profound jaundice (serum bilirubin\>10 mg/dL) accompanied by altered consciousness beyond Stage II or massive ascites; 6.Pregnancy or lactation; 7. Inability to provide informed consent.
Who the study is looking for
- -1. The patient must be aged\>18 years; 2. The diagnosis of portal hypertension must be confirmed, with gastroscopy revealing severe esophageal varices and a positive red sign; 3. For patients undergoing endoscopic variceal ligation (EVL) due to esophageal varices (including those with hemorrhage or those eligible for elective ligation), successful intraoperative ligation is achieved (achieving hemostasis or completing the predetermined ligation procedure).
- 4\. Sign the informed consent form
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (12)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Fifth People's Hospital of Anyang Coordinator of this site? Confirm its status | Anyang | China | Recruiting |
| The Secend People's Hospital of Jiaozuo Coordinator of this site? Confirm its status | Jiaozuo | China | Recruiting |
| Huaihe Hospital of Henan University Coordinator of this site? Confirm its status | Kaifeng | China | Recruiting |
| Luohe Central Hospital Coordinator of this site? Confirm its status | Luohe | China | Recruiting |
| Luoyang Central Hospital Coordinator of this site? Confirm its status | Luoyang | China | Recruiting |
| Nanyang Central Hospital Coordinator of this site? Confirm its status | Nanyang | China | Recruiting |
| Sanmenxia Central Hospital Coordinator of this site? Confirm its status | Sanmenxia | China | Recruiting |
| Shangqiu Municipal Hospital Coordinator of this site? Confirm its status | Shangqiu | China | Recruiting |
| The First Affiliated Hospital of Xinxiang Medical University Coordinator of this site? Confirm its status | Xinxiang | China | Recruiting |
| Xuchang Central Hospital Coordinator of this site? Confirm its status | Xuchang | China | Recruiting |
| The First Affiliated Hospital of Zhengzhou University Coordinator of this site? Confirm its status | Zhengzhou | China | Recruiting |
| Zhoukou Central Hospital Coordinator of this site? Confirm its status | Zhoukou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.