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NCT07775196Not yet recruiting

Aging and Exercise Impacts on Glymphatic Function

Impact of Aging and Exercise on Glymphatic Function Using Multi-modal MRI

Source: ClinicalTrials.gov · Last updated 5 Oct 2026

Brief summary (registry, in English)

This is a prospective, interventional, non-blinded, single center research project that will recruit cognitively unimpaired subjects in the 25-55 year old and 55-75 year old range. This study will use acute aerobic exercise as a natural intervention model to increase cardiac activity which may further drive the glymphatic function. There will be no randomization, and all enrolled subjects will participate in the exercise session. Hypotheses: revealed by the multi-modal magnetic resonance imaging (MRI) approach, glymphatic dysfunction increases with age and is associated with preclinical Alzheimer's Disease (AD) pathology in cognitively unimpaired individuals. Using acute aerobic exercise as a human model, the enhancement of cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange caused by elevated cardiac activity and paravascular cerebrospinal fluid (pCSF) dynamics can be validated.

Status (registry)
Not yet recruiting
Study type
Interventional
Enrollment
240 (estimated)
First submitted
12 Aug 2026
Start date
1 Dec 2026
Primary completion date
31 Dec 2029
Lead sponsor
University of Texas Southwestern Medical Center
NCT number
NCT07775196

What you commit to

  • Study type: Interventional
  • Planned participants: 240
  • From 1 Dec 2026 to the primary completion date, 31 Dec 2029
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • history of prior head trauma, significant autoimmune disorders,
  • prior or current alcoholism or drug abuse;

Other illness

  • history of stroke or other major cerebrovascular disease;
  • diagnosis of Alzheimer's disease (AD) or other types of dementia;
  • diagnosis of major neurologic and psychiatric disorders (e.g., Parkingson's disease, major depression);
  • major systemic illness likely to affect the central nervous system, e.g., uncontrolled diabetes, severe cardiovascular disease, cancer, etc.;
  • resistant hypertension (SBP ≥140 or DBP ≥ 90 mmHg despite 3 antihypertensive drugs at maximal doses);
  • any conditions judged by the investigators to be medically inappropriate, risky or likely to cause poor study compliance.

Other

  • pregnant women
  • sleep apnea;
  • orthostatic hypotension defined as the third standing systolic blood pressure (SBP) \< 100mmHg; any contraindications to having a MRI, e.g., claustrophobia, pacemaker or other medical device of metal;

Who the study is looking for

  • age 25-75 years old
  • cognitively unimpaired (CU)
  • Mini-Mental State Examination (MMSE) score ≥27 at enrollment screening
  • matched gender
  • all racial/ethnic groups

Age in the registry: 25 years to 75 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.