NCT07775326Completed
Dietary Macronutrients and Metabolic Markers
Effects of a 12-Week Ketogenic Diet on Thyroid Function and Glucose-Insulin Metabolism in Premenopausal Women Across Different Adiposity Categories
Source: ClinicalTrials.gov · Last updated 24 Aug 2026
Brief summary (registry, in English)
This prospective 12-week dietary intervention study evaluated the effects of a ketogenic diet on thyroid function and glucose-insulin metabolism in premenopausal women aged 30-50 years across different adiposity categories. Participants followed an individualized low-carbohydrate ketogenic diet designed to induce and maintain nutritional ketosis. Thyroid-related outcomes included thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4). Glucose-insulin metabolism was assessed using fasting glucose, fasting insulin, glycated hemoglobin (HbA1c), and the homeostatic model assessment of insulin resistance (HOMA-IR). Changes in body mass and anthropometric parameters were also evaluated. Outcomes were assessed before and after the 12-week intervention and compared according to baseline BMI categories.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 120 (actual)
- First submitted
- 16 Aug 2026
- Start date
- 3 Mar 2025
- Primary completion date
- 16 Dec 2025
- Lead sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
- Diseases
- Obesity
- NCT number
- NCT07775326
What you commit to
- Study type: Interventional
- Participants enrolled: 120
- From 3 Mar 2025 to the primary completion date, 16 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previously diagnosed thyroid disease
- Thyroid hormone replacement therapy
- Use of antithyroid medication
Lab values
- Use of dietary supplements known to substantially affect glucose or lipid metabolism before enrollment
Other
- Postmenopausal status
- Pregnancy or breastfeeding
- Use of other pharmacological treatments known to substantially affect thyroid function
- Use of pharmacological treatment for insulin resistance
- Use of pharmacological treatment for dyslipidemia
Who the study is looking for
- Premenopausal status
- No use of a specific diet, calorie-restricted diet, or food-elimination regimen during the preceding 12 months
- Willingness to follow the prescribed ketogenic diet for 12 weeks
- Provision of written informed consent
Age in the registry: 30 years to 50 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education in Katowice Coordinator of this site? Confirm its status | Katowice | Poland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.