NCT07775534Recruiting
Tear Fluid for the Detection of Tumor-associated Extracellular Vesicles in Glioblastoma Patients
Molecular Analysis of Tear Fluid Collected From Glioblastoma Patients: A Two-Phased Pilot Study
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
This clinical trial tests the impact of tear fluid in detecting tumor-associated extracellular vesicles (TEVs) in patients with glioblastoma. Brain tumors release small particles, called TEVs, that may provide information about the tumor, including how it responds to treatment. These particles can be found in cerebrospinal fluid (CSF), which is the fluid that surrounds the brain and spinal cord. Collecting CSF can be difficult and expensive, especially if samples are needed frequently to track these particles over time. Tear fluid is easier to collect than spinal fluid. If tears are found to contain similar tumor-related particles, changes in the tumor may be tracked by studying the particles found in tear fluid.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 17 Aug 2026
- Start date
- 23 Oct 2026
- Primary completion date
- 1 Feb 2029
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Glioblastoma
- NCT number
- NCT07775534
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 23 Oct 2026 to the primary completion date, 1 Feb 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recent ocular surgery (within 3 months)
Other illness
- Active ocular infection or inflammation
- Known allergy or hypersensitivity to topical anesthetics
- Cognitive impairment
- Any condition that, in the opinion of the investigator, would interfere with the participant's ability to comply with study procedures or place the participant at undue risk
Other
- Chronic dry eyes
- Pregnancy
Who the study is looking for
- Adults (age ≥ 18)
- Male and female
- All racial and ethnic groups
- Pathologically-proven diagnosis of GBM or healthy volunteers
- For GBM patients, presence of a previously placed Rickham reservoir or shunt
- Able to provide informed consent (or via legal representative)
- Willing to undergo Schirmer strip procedure
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.