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NCT07776054RecruitingPhase 4

Clinical Impact of SGLT2 Inhibitor After DC Cardioversion in Persistent AF With HFpEF

Clinical Impact of SGLT2 Inhibitor After DC Cardioversion in Persistent Atrial Fibrillation Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Controlled Trial

Source: ClinicalTrials.gov · Last updated 20 Aug 2026

Brief summary (registry, in English)

SGLT2 inhibitors improve outcomes in heart failure across the ejection fraction spectrum, but their effect on maintenance of sinus rhythm after rhythm-control therapy is largely unknown. This prospective, single-center, open-label randomized controlled trial evaluates whether an SGLT2 inhibitor started after successful electrical cardioversion reduces recurrence of atrial tachyarrhythmia at 1 month in patients with persistent atrial fibrillation and heart failure with preserved ejection fraction. 200 patients will be randomized 1:1 to receive an SGLT2 inhibitor or no SGLT2 inhibitor.

Status (registry)
Recruiting
Phase (registry)
Phase 4
Study type
Interventional
Enrollment
200 (estimated)
First submitted
17 Aug 2026
Start date
1 Feb 2024
Primary completion date
1 Aug 2027
Lead sponsor
Samsung Medical Center
NCT number
NCT07776054

What you commit to

  • Study type: Interventional · Phase 4
  • Planned participants: 200
  • From 1 Feb 2024 to the primary completion date, 1 Aug 2027
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Previous use of an SGLT2 inhibitor

Other

  • Intracardiac thrombus on transesophageal echocardiography
  • Refusal to participate

Who the study is looking for

  • Age ≥19 years
  • Persistent atrial fibrillation
  • H2FPEF score ≥6 or HFA-PEFF score ≥5
  • Restoration of sinus rhythm after electrical cardioversion

Age in the registry: 19 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Samsung Medical Center
Coordinator of this site? Confirm its status
SeoulSouth KoreaRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.