NCT07780045Not yet recruiting
SII and SIRI as Prognostic Biomarkers in Lupus Nephritis
Emerging Inflammatory Biomarkers (SII and SIRI) for Predicting Disease Activity, Renal Flares and Outcomes in Lupus Nephritis: A Prospective Observational Study
Source: ClinicalTrials.gov · Last updated 24 Aug 2026
Brief summary (registry, in English)
This prospective observational study aims to evaluate the prognostic utility of the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) as novel inflammatory biomarkers for monitoring disease activity and predicting renal progression, flares, and outcomes in patients with lupus nephritis.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 19 Aug 2026
- Start date
- 19 Aug 2026
- Primary completion date
- 19 Aug 2027
- Lead sponsor
- Assiut University
- Diseases
- Lupus (SLE)
- NCT number
- NCT07780045
What you commit to
- Study type: Observational
- Planned participants: 100
- From 19 Aug 2026 to the primary completion date, 19 Aug 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active infection, sepsis, or other concurrent inflammatory or autoimmune conditions
Lab values
- Malignancy or hematologic disorders affecting blood cell counts
- Use of medications significantly affecting blood counts (such as recent chemotherapy or G-CSF)
Other
- Pregnancy
- Incomplete medical records or anticipated loss to follow-up
Who the study is looking for
- Age ≥ 18 years
- Diagnosis of systemic lupus erythematosus according to the 2019 EULAR/ACR classification criteria
- Confirmed lupus nephritis according to ISN/RPS classification
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.