REFOCUS-HTN US-WEST: A Data Infrastructure to Characterize Individuals With Hypertension

Prior treatment

• Bariatric surgery or GLP1 prescription in the last 12 months;
• Exposure to an aldosterone synthase inhibitor or a mineralocorticoid receptor antagonist in the last 12 weeks;
• Kidney transplant;
• Currently receiving dialysis;

Other illness

• Diagnosed cause of secondary hypertension from drug or alcohol induced, or renovascular hypertension;

Other

• Last known estimated glomerular filtration rate \< 45 mL/min/1.73m2 (according to the CKD-EPI equation) at the time of screening;
• Current enrollment in any cardiovascular or blood pressure interventional trial.

• The SCALED Cohort will be identified from the REFOCUS-HTN Cohort which includes men and women ≥ 18 years of age with established hypertension in the KPNC EHR from January 2012 through March 31, 2029. Established hypertension will be defined as one of the following:
• ≥1 outpatient, non-emergency department diagnosis of hypertension;
• ≥2 consecutive outpatient measures of systolic blood pressure ≥130 mmHg at least 90 days apart;
• ≥2 consecutive outpatient measures of diastolic blood pressure ≥80 mmHg at least 90 days apart.
  • Additional Eligibility Criteria for SCALED:
• Hypertension diagnosis within the past 18 months prior to screening.
• At least 6 months of continuous health plan coverage prior to initial visit.