NCT07781501Recruiting
Long-Term Study of COVID-19 Infection and Long COVID
Longitudinal Study of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Post-Acute Sequelae of COVID-19 (PASC)
Source: ClinicalTrials.gov · Last updated 28 Sept 2026
Brief summary (registry, in English)
This study will examine how common Long COVID is and how symptoms may persist over time in people who have previously had COVID-19. Researchers will collect information about participants' health and symptoms through questionnaires and may collect saliva and other non-invasive oral samples. The study will also examine biological factors in these samples that may be associated with persistent symptoms. The goal is to better understand why some people develop Long COVID and identify factors that may help predict who is more likely to experience persistent symptoms.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 19 Aug 2026
- Start date
- 4 Sept 2024
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- University of North Carolina, Chapel Hill
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT07781501
What you commit to
- Study type: Observational
- Planned participants: 500
- From 4 Sept 2024 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Oral viral or bacterial infection within the previous 30 days.
- Active alcohol or drug abuse.
Other illness
- Current severe periodontal disease with bleeding gums.
- Current oral herpes flare, aphthous ulcer, or oral candidiasis (thrush).
- Medical or genetic syndrome or developmental delay that would prevent completion of study procedures or questionnaires.
Other
- Dry mouth that would prevent adequate saliva collection.
Who the study is looking for
- Age 18 to 75 years.
- Previous laboratory-confirmed SARS-CoV-2 infection.
- Willing and able to provide informed consent.
- Able to complete study questionnaires and study procedures.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of North Carolina Coordinator of this site? Confirm its status | Chapel Hill | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.