NCT07782034Completed
40-Hz Audiovisual Stimulation in Schizophrenia Spectrum Disorders
Effects of 40-Hz Binaural Beat Music Combined With Rhythmic Photic Stimulation on Psychological Distress, Anxiety, Cognitive Function, and Electroencephalographic Spectral Activity in Patients With Schizophrenia Spectrum Disorders: A Sham-Controlled Randomized Trial
Source: ClinicalTrials.gov · Last updated 24 Aug 2026
Brief summary (registry, in English)
This randomized, sham-controlled trial evaluated the effects of 40-Hz binaural beat music (BBM) combined with 40-Hz rhythmic photic stimulation (RPS) in adults with schizophrenia spectrum disorders. A total of 55 participants with schizophrenia or schizoaffective disorder were randomly assigned to either the BBM plus RPS group or a sham control group. Participants received 20-minute sessions three times per week for 12 consecutive weeks, for a total of 36 sessions. The primary outcome was anxiety measured using the Beck Anxiety Inventory (BAI). Secondary outcomes included psychological distress measured using the Five-item Brief Symptom Rating Scale (BSRS-5) and global cognitive function measured using the Mini-Mental State Examination (MMSE). Electroencephalographic (EEG) relative power across delta, theta, alpha, beta, and gamma frequency bands was also assessed as an exploratory physiological outcome.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 55 (actual)
- First submitted
- 19 Aug 2026
- Start date
- 1 Feb 2024
- Primary completion date
- 30 Jun 2024
- Lead sponsor
- National Cheng Kung University
- Diseases
- Schizophrenia
- NCT number
- NCT07782034
What you commit to
- Study type: Interventional
- Participants enrolled: 55
- From 1 Feb 2024 to the primary completion date, 30 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Acute illness episode or unstable physical condition.
- History of epilepsy or risk of seizures.
Other
- Substance abuse.
- Impaired or disturbed consciousness.
Who the study is looking for
- Diagnosis of schizophrenia or schizoaffective disorder according to DSM-5 criteria, made by a board-certified psychiatrist at least 1 year prior to enrollment.
- Age 20 to 60 years.
- Stable psychiatric symptoms, with no adjustment of major psychotropic medications for at least 2 consecutive months.
- No severe hearing impairment.
- 4\. Current participation in a day-care program, community rehabilitation center, or rehabilitation ward.
Age in the registry: 20 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Asia Univeraity Coordinator of this site? Confirm its status | Taichung | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.