NCT07784712Not yet recruiting
Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis
Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis in At-Risk Population: A Prospective Study
Source: ClinicalTrials.gov · Last updated 25 Aug 2026
Brief summary (registry, in English)
People eligible for this study have had the suggestion from their doctor to receive a cardiac pacemaker or defibrillator to treat a cardiac condition as part of their routine care. We are doing this study to understand if obtaining a tissue sample from their body during a device implant may assist in the early diagnosis of Transthyretin Cardiac Amyloidosis (ATTR-CM).
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 70 (estimated)
- First submitted
- 21 Aug 2026
- Start date
- Oct 2026
- Primary completion date
- Apr 2028
- Lead sponsor
- Geisinger Clinic
- Diseases
- Amyloidosis, Heart failure
- NCT number
- NCT07784712
What you commit to
- Study type: Observational
- Planned participants: 70
- From Oct 2026 to the primary completion date, Apr 2028
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Enrolled in a concurrent study that may confound the results of this study
Other
- Inability to provide informed consent
- Pregnant
Who the study is looking for
- Age≥65(or 50-64 with hereditary-ATTR risk: family history of ATTR or known TTR variant)
- Patients with an indication for permanent pacemaker or CRT or ICD device
- Patients willing to comply with all study procedures and be available for the duration of the study. And any one of the following:
- Diagnosis of atrial fibrillation or sinus node dysfunction Diagnosis of AV block Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction Evidence for infiltrative cardiomyopathy Unexplained renal insufficiency Peripheral neuropathy Family h/o cardiomyopathy Family h/o peripheral neuropathy Carpal tunnel syndrome, unprovoked tendon rupture Hip or knee arthroplasty Unexplained RV or LV wall thickening on echocardiogram Unexplained, persistent low-level elevation of cardiac troponins Unexplained orthostatic hypotension Discordance between QRS voltage on ECG and wall thickness on echo Black race Spinal stenosis IVS thickness ≥ 1.2cm (by TTE or cardiac MRI)
Age in the registry: 50 years to 105 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.