NCT07785375Not yet recruiting
Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation
Randomized Clinical Trial of the Efficacy of Extracorporeal Carbon Dioxide Removal and Noninvasive Ventilation in Patients With COPD Not Eligible for Endotracheal Intubation
Source: ClinicalTrials.gov · Last updated 25 Aug 2026
Brief summary (registry, in English)
This study will evaluate whether adding extracorporeal carbon dioxide removal (ECCO2R) to noninvasive ventilation can improve breathing in adults hospitalized with a severe worsening of chronic obstructive pulmonary disease (COPD). Participants will have high carbon dioxide levels and increased acidity in their blood despite treatment with noninvasive ventilation and will not be eligible for invasive mechanical ventilation through a breathing tube. A total of 14 participants will be assigned by chance to receive either noninvasive ventilation alone or noninvasive ventilation together with ECCO2R. ECCO2R removes carbon dioxide directly from the blood through a catheter placed in a large vein. The main aim is to determine whether adding ECCO2R reduces the breathing rate within 4 hours. The study will also assess blood carbon dioxide and acidity, duration of noninvasive ventilation, length of hospital stay, survival, and complications related to ECCO2R.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 14 (estimated)
- First submitted
- 21 Aug 2026
- Start date
- Sept 2026
- Primary completion date
- Sept 2027
- Lead sponsor
- Hospital del Mar Research Institute (IMIM)
- Diseases
- COPD
- NCT number
- NCT07785375
What you commit to
- Study type: Interventional
- Planned participants: 14
- From Sept 2026 to the primary completion date, Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Contraindication to extracorporeal carbon dioxide removal due to a coagulation disorder.
Other
- Inability to establish adequate vascular access.
Who the study is looking for
- Age 18 years or older.
- Confirmed diagnosis of chronic obstructive pulmonary disease (COPD).
- Acute exacerbation of COPD, defined as increased dyspnea, cough, and/or sputum production.
- Acute hypercapnic respiratory failure requiring noninvasive ventilation, with arterial pH \<7.30 and PaCO2 \>50 mmHg.
- Not eligible for endotracheal intubation because of a medical decision or the participant's prior decision.
- Persistent respiratory acidosis, defined as arterial pH \<7.30 with PaCO2 \>45 mmHg, after 4 hours of noninvasive ventilation.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital del Mar Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.