NCT07786155Not yet recruiting
Effect of a Multimodal Antiemetic Protocol on Postoperative Nausea and Vomiting in Patients Undergoing Flap Surgery for Head and Neck Cancer
Effect of a Multimodal Antiemetic Protocol on Postoperative Nausea and Vomiting in Patients Undergoing Flap Surgery for Head and Neck Cancer: A Prospective Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 26 Aug 2026
Brief summary (registry, in English)
This prospective randomized controlled trial evaluates whether a multimodal antiemetic protocol can reduce postoperative nausea and vomiting (PONV) in patients undergoing flap surgery for head and neck cancer. Seventy-two patients will be randomized to receive either standard dexamethasone-based prophylaxis or a multimodal protocol incorporating TIVA, superficial cervical plexus block, palonosetron, dexamethasone, and acetaminophen. PONV, postoperative pain, quality of recovery, and other postoperative outcomes will be compared.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 72 (estimated)
- First submitted
- 21 Aug 2026
- Start date
- 1 Sept 2026
- Primary completion date
- 1 Sept 2028
- Lead sponsor
- Seoul National University Hospital
- Diseases
- Head and neck cancer
- NCT number
- NCT07786155
What you commit to
- Study type: Interventional
- Planned participants: 72
- From 1 Sept 2026 to the primary completion date, 1 Sept 2028
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients undergoing emergency surgery
Other illness
- Patients with a history of hypersensitivity or adverse reactions to ropivacaine
- Patients with difficulty completing questionnaires due to conditions such as dementia or delirium
- Patients with severe cardiopulmonary disease
Lab values
- Patients with QT prolongation on preoperative ECG Patients deemed unsuitable for participation by the investigator
Other
- Patients who do not consent to participate in the study
- Patients with signs of inflammation (such as erythema) at the nerve block injection site
Who the study is looking for
- Patients aged 19 years or older undergoing elective flap surgery for head and neck cancer
Age in the registry: 19 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.