NCT07786324Not yet recruiting
Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography
Comparison of 3% Hypertonic Saline Versus 20% Mannitol in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Optic Nerve Sheath Diameter Measurements''
Source: ClinicalTrials.gov · Last updated 25 Aug 2026
Brief summary (registry, in English)
The aim of this study to compare the efficacy of hypertonic saline and mannitol in reducing intracranial pressure, as assessed by serial optic nerve sheath diameter (ONSD) ultrasound measurements, in patients with traumatic brain injury.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 13 Aug 2026
- Start date
- 1 Oct 2026
- Primary completion date
- 30 Apr 2029
- Lead sponsor
- Assiut University
- NCT number
- NCT07786324
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 1 Oct 2026 to the primary completion date, 30 Apr 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- • Penetrating head injury.
- Hypotension.
- Previous ocular trauma or orbital surgery.
- Glaucoma or optic nerve pathology.
- Bilateral ocular injuries preventing ultrasound assessment.
- Pregnancy.
- Chronic renal failure requiring dialysis.
- Initial serum sodium \>150mmol/L or Patients reaching a sodium level \>160mmol/L during hypertonic administration.
- Previous hyperosmolar therapy before enrollment.
- Refusal of consent by legal surrogate.
Who the study is looking for
- • Age ≥18 years.
- Acute severe traumatic brain injury (TBI) (GCS 3-8) confirmed by CT brain.
- Elevated ONSD suggestive of raised ICP (ONSD cutoff value ≥5.6 mm ).(14)
- Initiation of hyperosmolar therapy within 24 hours of injury.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Assiut University Coordinator of this site? Confirm its status | Asyut | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.