A Study to Predict Atrial Fibrillation (AF) Burden in Participants With PAF and PsAF Treated With the VARIPULSE™ PFA Catheter

Prior treatment

• Participant has previous surgical or catheter ablation for AF
• Participant has severe dilatation of the LA (LAD \> 50 millimeter \[mm\]) of the antero-posterior diameter confirmed by imaging performed within 180 days prior to enrollment
• Participant has LA thrombus confirmed by imaging within 48 hours prior to the procedure
• Participant has had a thromboembolic event (including transient ischemic attack \[TIA\]) within 180 prior to enrollment
• Participant has had a percutaneous coronary intervention or acute myocardial infarction (MI) within 60 days prior to enrollment
• Participant has had coronary artery bypass grafting (CABG) surgery within 180 days prior to enrollment
• Participant has had unstable angina within 6 months prior to enrollment
• Participant is currently enrolled in another investigational device or drug study

Other illness

• Participant has AF secondary to electrolyte imbalance, thyroid disease, or reversible or non-cardiac cause (for example, untreated documented obstructive sleep apnea, acute alcohol toxicity, et cetera)
• Participant has uncontrolled heart failure or new york heart association (NYHA) Class III or IV
• Participant has a history of blood clotting, bleeding abnormalities or contraindication to anticoagulation (for example, heparin)
• Participant has had valvular cardiac surgical/percutaneous procedure (for example, ventriculotomy, atriotomy, valve repair or replacement, and presence of a prosthetic valve)
• Participant has anticipated cardiac transplantation, cardiac surgery, or other major surgery within the next 365 days post-procedure
• Participant has significant pulmonary disease (for example, restrictive pulmonary disease, constrictive or chronic obstructive pulmonary disease) or any other disease or malfunction of the lungs or respiratory system that produces severe chronic symptoms
• Participant has an acute illness, active systemic infection, or sepsis
• Participant has an implanted metal cardiac device, including MitraClip and left atrial appendage occlusion (LAAO) devices (for example, WATCHMAN, Amulet, et cetera.) (this exclusion does not include coronary stents, implanted pacemakers, implantable cardioverter-defibrillators (ICD), and an implantable loop recorders (ILR))
• Participant has a condition that precludes vascular access (such as inferior vena cava (IVC) filter)

Lab values

• Participant has severely compromised left ventricular ejection fraction (LVEF \< 40 percent \[%\]) confirmed by imaging performed within 180 days prior to enrollment

Other

• Participant has continuous AF \> 365 days (longstanding persistent AF)
• Participant is known to require ablation outside the left atrium (LA), superior vena cava (SVC), and cavotricuspid isthmus (CTI) region (for example, atrioventricular reentrant tachycardia, atrioventricular nodal reentry tachycardia, ventricular tachycardia and wolff-parkinson-white)
• Participant has a significant congenital anomaly (for example, atrial septal defects \[ASDs\]) including repaired defects or medical problems that in the opinion of the Investigator would preclude enrollment in this study
• Participant has an existing diagnosis of pulmonary vein stenosis (PVS)
• Participant has a pre-existing hemi-diaphragmatic paralysis
• Participant has an intracardiac thrombus, myxoma, tumor, interatrial baffle or patch or other abnormality that precludes catheter introduction or manipulation
• Participant has severe mitral regurgitation (Regurgitant volume greater than or equal to (\>=) 60 milliliter per beat (mL/beat), regurgitant fraction \>= 50%, and/or effective regurgitant orifice area \>=0.40 centimeter square \[cm\^2\])
• Participant is pregnant, lactating, or is of child-bearing potential and plans on trying to become pregnant during the course of the clinical investigation
• Participant has a life expectancy less than 365 days

• Participant has been diagnosed with either atrial fibrillation (AF) subtype (paroxysmal (AF episodes that start suddenly and typically last less than 7 days, often resolving in 24 hours) or persistent (AF lasting more than 7 days in duration and less than 365 days in duration, documented by )):
  • A physician's note documenting diagnosis of symptomatic PAF/PsAF, as defined above AND
  • PAF: At least one (1) AF episode electrocardiographically documented within 12 months prior to enrollment
  • PsAF: Two electrocardiograms (ECGs) showing continuous AF, with electrocardiogram taken at least 7 days apart (electrocardiograms cannot be more than (\>) 365 days prior to enrollment) OR A 24-hour arrhythmia monitor documenting continuous AF within the last 365 days
• Participant is aged 18-80 years at the time of informed consent
• Participant is willing and capable of providing informed consent
• Participant is able and willing to comply with all pre-, post-, and follow-up testing and requirements