NCT07789795Recruiting
Hemodynamic Effects of Bilateral and Unilateral Spinal Anesthesia Using the Continuous Pressure Recording Analytical Method.
Comparison of the Hemodynamic Effects of Bilateral and Unilateral Spinal Anesthesia in Hip Arthroplasty Surgeries in Elderly Patients Using the Continuous Pressure Recording Analytical Method.
Source: ClinicalTrials.gov · Last updated 27 Aug 2026
Brief summary (registry, in English)
This randomized controlled study aims to compare the intraoperative hemodynamic effects of unilateral and bilateral spinal anesthesia in elderly patients undergoing elective total hip arthroplasty. Seventy-four patients aged 65 years and older will be randomized into two groups: unilateral spinal anesthesia (n=37) and bilateral spinal anesthesia (n=37). Hemodynamic parameters including cardiac output, stroke volume, stroke volume variation, pulse pressure variation, and systemic vascular resistance will be continuously monitored using the Pressure Recording Analytical Method (PRAM)-based MostCare monitoring system. Intraoperative fluid requirements and vasopressor consumption will also be evaluated. The study seeks to determine whether unilateral spinal anesthesia provides greater hemodynamic stability and reduces the need for fluid administration and vasopressor support compared with conventional bilateral spinal anesthesia in elderly patients undergoing hip arthroplasty.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 74 (estimated)
- First submitted
- 11 Jun 2026
- Start date
- 1 May 2026
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- Kayseri City Hospital
- Diseases
- Stroke
- NCT number
- NCT07789795
What you commit to
- Study type: Interventional
- Planned participants: 74
- From 1 May 2026 to the primary completion date, 31 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of previous major neurosurgical intervention.
- Severe spinal deformity (e.g., severe scoliosis, previous spinal fusion surgery, or spinal trauma).
Other illness
- Anatomical abnormality, vascular defect, or infection at the site intended for arterial catheter placement for PRAM monitoring.
- Presence of skin infection or systemic infection/sepsis.
- Severe hypovolemia or decompensated cardiac disease in which spinal anesthesia is contraindicated.
- Known allergy or hypersensitivity to local anesthetics or sedative agents.
- Local infection or wound at the planned spinal puncture site.
Lab values
- Current anticoagulant therapy or coagulopathy (INR \>1.5 or platelet count \<75,000/mm³).
Age
- Age below 65 years.
Other
- Glasgow Coma Scale (GCS) score \<13.
- Clinical contraindication to spinal anesthesia (e.g., increased intracranial pressure, septicemia, or severe hypotension). -
Who the study is looking for
- Adults aged 65 years and older.
- Patients scheduled for elective total hip arthroplasty.
- Patients with an American Society of Anesthesiologists (ASA) physical status classification of II, III, or IV.
- Patients with a Glasgow Coma Scale (GCS) score of 13-15 who are conscious and able to cooperate.
- Patients with suitable peripheral arterial anatomy for PRAM monitoring.
- Patients who provide written informed consent to participate in the study.
- Patients without any clinical contraindication to spinal anesthesia. -
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kayseri City Hospital Coordinator of this site? Confirm its status | Kayseri | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.