NCT07790718Recruiting
Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer
The Effects of Exercise on Colorectal Cancer Promotion Following Pelvic Radiotherapy for Prostate Cancer
Source: ClinicalTrials.gov · Last updated 28 Aug 2026
Brief summary (registry, in English)
This clinical trial evaluates the effects of exercise therapy on signs of colorectal cancer in colon tissue and blood in people who completed pelvic radiation therapy for prostate cancer. People who get radiation in the pelvic area have a higher chance of developing colon cancer years later. This is because radiation can cause new mutations and inflammation. Research shows that exercise lowers colon cancer risk by about 30%. The results of this trial may help researchers better understand how exercise affects the development of colorectal cancer in patients who were treated with pelvic radiation therapy for prostate cancer.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 17 Aug 2026
- Start date
- 16 Dec 2026
- Primary completion date
- 12 Jun 2027
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Prostate cancer, Colorectal cancer
- NCT number
- NCT07790718
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 16 Dec 2026 to the primary completion date, 12 Jun 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of any other concurrent, actively treated malignancy
Other illness
- Distant metastatic malignancy of any kind
- Any other condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures
Other
- Enrollment in any other program (e.g., weight loss program) that may alter the impact of exercise on outcomes
- Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility/logistics)
Who the study is looking for
- Documented informed consent of the participant and/or legally authorized representative
- Assent, when appropriate, will be obtained per institutional guidelines
- Agreement to allow the use of archival tissue from diagnostic tumor biopsies
- If unavailable, exceptions may be granted with study principal investigator (PI) approval
- Age: 40-80 years
- Body mass index (BMI): \> 25 kg/m\^2
- Has Apple Health application (app) on personal device with valid iOS operating software (i.e., iOS 15.0 or higher)
- Has a registered MyChart/MyCityofHope account (or be willing to register for one) and the app downloaded onto personal device
- Ability to read and understand English to review MyChart/MyCityofHope on-screen instructions to sync and share Apple Health data, and for safety during exercise testing
- Previously diagnosed with localized prostate cancer
- Completed pelvic radiotherapy 12-20 months ago
- Presence of abnormalities (e.g., polyps, lesions) in the colon
- Assessed for exercise participation as per pre-screening clearance via the Physical Activity Readiness Questionnaire (PAR-Q+) (stage 2 only)
- Low physical activity, defined by \< 5,000 steps/day over the last 12 months as per Apple Health data (stage 2 only)
Age in the registry: 40 years to 80 years · Sex: Male · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
| City of Hope at Irvine Lennar Coordinator of this site? Confirm its status | Irvine | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.