NCT07791212Not yet recruiting
Dissecting Immunological and Autoimmune Mechanisms of Neuropsychiatric Diseases
Source: ClinicalTrials.gov · Last updated 27 Aug 2026
Brief summary (registry, in English)
The goal of this observational cohort study is to investigate the role of immune system in neuropsychiatric symptoms (NPS) and to identify immunological biomarkers that may improve the diagnosis, prognosis, and future treatment of immune-related neuropsychiatric disorders in individuals aged 16-100 years with suspected immune-mediated neuropsychiatric symptoms and matched control participants without neuropsychiatric symptoms. The main questions it aims to answer are what immunological mechanisms are associated with neuropsychiatric symptoms across a range of neurological, psychiatric, autoimmune, infectious, and inflammatory conditions. Also, if immunological biomarkers can be identified that may support the diagnosis, prognosis, and future treatment of neuropsychiatric disorders in which the immune system may play a role. Participants will provide a blood sample for immunological analysis and may optionally provide a cerebrospinal fluid (CSF) sample if a suitable previously collected sample is not available. Researchers may also analyse existing clinical and biological samples where available. Participants will provide demographic and clinical information, allow access to relevant medical record data, and may optionally provide additional blood samples, up to four times within one year, for further biomarker and immunological analyses.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 300 (estimated)
- First submitted
- 24 Aug 2026
- Start date
- 1 Oct 2026
- Primary completion date
- 1 Oct 2036
- Lead sponsor
- King's College London
- Diseases
- Schizophrenia
- NCT number
- NCT07791212
What you commit to
- Study type: Observational
- Planned participants: 300
- From 1 Oct 2026 to the primary completion date, 1 Oct 2036
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Significant lower spinal deformity (such as spina bifida), injury, or disease (such as stenosis) or previous lower spinal surgery.
- Antiplatelet or anticoagulant therapy within the 14 days prior to Lumbar Puncture procedure.
Other illness
- Known or suspected clotting disorder.
- Known or suspected allergy to local anaesthetic agent or an ingredient of the anaesthetic solution.
- History of chronic or recurrent headaches, in the opinion of the investigator.
Lab values
- Clinically significant abnormality in full blood count.
Other
- All Participants:
- Unacceptable risk of harm to participant or study staff due to risk of behavioural disturbance.
- Inability to have blood tests.
- Optional Lumbar Puncture only:
- Known or suspected raised intracranial pressure, assessed by study clinician.
Who the study is looking for
- Participants with Neuropsychiatric symptoms
- Age 16-100.
- Current or previous neuropsychiatric symptoms within the last year.
- Suspicion of immunological contribution to the aetiology of their neuropsychiatric symptoms.
- Control Participants
- Age 16-100.
- No current or previous self-report of neuropsychiatric symptoms within the last year.
- Optional Lumbar Puncture only:
- \- Documented full blood count within the last 3 months with no clinically significant abnormalities.
Age in the registry: 16 years to 100 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| King's College Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| South London and Maudsley NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.