NCT07791979Not yet recruiting
High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease
High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease: A Single-Arm Simon Two-Stage Study
Source: ClinicalTrials.gov · Last updated 28 Aug 2026
Brief summary (registry, in English)
Hypoxemia is the most common adverse event during propofol sedation for gastrointestinal endoscopy in patients with chronic obstructive pulmonary disease (COPD) due to diminished pulmonary reserve. Although high-flow nasal cannula (HFNC) oxygenation has been shown to effectively reduce hypoxemia during sedated endoscopy in obese patients, its application in COPD patients remains an evidence gap, largely owing to the traditional concern that high-concentration oxygen may suppress respiratory drive and exacerbate CO₂ retention. This study aims to investigate whether HFNC can reduce the incidence of hypoxemia during sedated gastrointestinal endoscopy in patients with COPD.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 23 Aug 2026
- Start date
- 29 Aug 2026
- Primary completion date
- 23 Feb 2027
- Lead sponsor
- Zhejiang University
- Diseases
- COPD, Gastric and esophageal cancer
- NCT number
- NCT07791979
What you commit to
- Study type: Interventional
- Planned participants: 90
- From 29 Aug 2026 to the primary completion date, 23 Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with absolute contraindications to high-flow therapy, including but not limited to confirmed diagnosis of complete upper airway obstruction, basilar skull fracture or nasal bone fracture, pneumothorax, or pneumomediastinum.;
Other illness
- Known allergy to sedative agents such as propofol;
- Any other condition deemed by the investigator to make the patient unsuitable for trial participation.
Other
- American Society of Anesthesiologists (ASA) Physical Status class ≥ IV;
- Requirement for planned endotracheal intubation;
- Existing tracheostomy;
- Confirmed pregnancy or currently breastfeeding;
- Current participation in another interventional clinical trial;
Who the study is looking for
- Age ≥18 years;
- Confirmed diagnosis of chronic obstructive pulmonary disease (COPD);
- Scheduled for elective sedated gastroenteroscopy (gastroscopy, colonoscopy, or combined gastroscopy and colonoscopy);
- Expected procedure duration ≤45 minutes;
- Provision of written informed consent by the participant.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital Zhejiang University School of Medicine Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.