NCT07791992Withdrawn
Combination of High-flow Nasal Oxygen (Optiflow) and Vibrating Membrane Nebuliser (Aerogen) in the Pre-hospital Setting - Before/After Study
Source: ClinicalTrials.gov · Last updated 28 Aug 2026
Brief summary (registry, in English)
The aim of this observational before/after study is to determine how to optimally administer oxygen to patients experiencing an asthma or COPD exacerbation in emergency medical services. The aim will be to determine which method will achieve the target oxygen saturation objectives: \> 95% in asthma exacerbations and between 88% and 92% (or \> 92% in ambient air or with FiO2 21%) in COPD exacerbations. The study will compare a group "before" receiving standard care with a nebulizer mask to a group "after" using a combination of a vibrating membrane nebulizer and high-flow nasal oxygen.
- Status (registry)
- Withdrawn
- Study type
- Observational
- Enrollment
- 0 (actual)
- First submitted
- 28 Apr 2026
- Start date
- 1 Oct 2026
- Primary completion date
- 1 Oct 2027
- Lead sponsor
- Centre Hospitalier Sud Francilien
- Diseases
- Asthma
- NCT number
- NCT07791992
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Clinical signs of hypercapnia
- Non French speaker
- Contraindications to high-flow nasal oxygen: haemodynamic instability, Glasgow \< 12, cardiorespiratory arrest, lack of airway protection, cardiogenic pulmonary oedema
- Indication for orotracheal intubation
Who the study is looking for
- ≥ 18 years of age
- Exacerbation of asthma or COPD requiring nebulization
- Free and informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier Sud Francilien Coordinator of this site? Confirm its status | Corbeil-Essonnes | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.