NCT07792265Completed
Anesthesia and Postoperative Delirium in Parkinson DBS
A Prospective Cohort Study on Anesthesia-Related Neuroprotective Mechanisms and Prediction Models for Postoperative Delirium After Deep Brain Stimulation in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 28 Aug 2026
Brief summary (registry, in English)
Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a rising incidence due to global aging. Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is a core therapeutic modality for motor symptoms in patients with moderate-to-advanced PD. However, Postoperative Delirium (POD) is a common and significant complication following DBS surgery, affecting up to 42.6% of patients. POD is associated with prolonged hospitalization, increased medical costs, and poorer neurological prognosis. Current evidence regarding the incidence of POD after STN-DBS and the impact of different anesthesia management strategies remains limited, with a lack of large-scale prospective studies. This study aims to prospectively investigate the incidence, risk factors, and anesthesia-related neuroprotective mechanisms of POD in PD patients undergoing STN-DBS. Specifically, the study seeks to: Determine the incidence of POD within 3 days postoperatively. Analyze the correlation between anesthesia management (including anesthetic agents, depth, and hemodynamics) and the occurrence of POD. Explore the interaction between POD and postoperative non-motor symptoms such as pain, sleep disturbances, and long-term cognitive function. Construct a multidimensional prediction model for POD based on preoperative and intra-operative data.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 400 (actual)
- First submitted
- 29 Apr 2026
- Start date
- 1 May 2022
- Primary completion date
- 31 Jan 2026
- Lead sponsor
- Beijing Tiantan Hospital
- Diseases
- Parkinson disease
- NCT number
- NCT07792265
What you commit to
- Study type: Observational
- Participants enrolled: 400
- From 1 May 2022 to the primary completion date, 31 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe dysfunction of vital organs (e.g., heart failure, renal or hepatic dysfunction)
- History of allergy to anesthetic agents
Other
- Obstructive sleep apnea
- Body mass index (BMI) \>30 kg/m²
- Predicted difficult airway
- Severe preoperative anxiety
Who the study is looking for
- Aged 50-80 years old
- American Society of Anesthesiologists (ASA) physical status classification II-III
- Scheduled for bilateral subthalamic nucleus deep brain stimulation (STN-DBS) for Parkinson's disease
- Signed informed consent prior to enrollment
Age in the registry: 50 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Tian Tan Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.