NCT07792811Not yet recruitingPhase 2/3
Non-Invasive Deep Brain Stimulation for Upper Limb Recovery After Stroke (NIMBUS)
Non-Invasive neuroModulation of Deep Brain Structures for Upper Limb Recovery After Stroke by Transcranial Temporal Interference Electric Stimulation.
Source: ClinicalTrials.gov · Last updated 28 Aug 2026
Brief summary (registry, in English)
NIMBUS is a clinical study evaluating a new, non-invasive brain stimulation treatment to improve arm and hand function in people with long-term effects of stroke. The treatment uses a personalized method to stimulate deeper areas of the brain through the scalp, without surgery, while participants undergo intensive physiotherapy rehabilitation. Physiotherapy in combination with the brain stimulation will occur three times a day over the course of a week. In the study, participants are randomly assigned to receive either the active treatment or a sham (inactive) version, so researchers can compare the outcomes fairly. The study will assess whether the treatment is safe, feasible, and effective by measuring changes in arm movement, daily activities, and brain function before and after the treatment. The goal is to determine whether this approach can enhance recovery after stroke and support the development of improved rehabilitation therapies.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 84 (estimated)
- First submitted
- 5 Aug 2026
- Start date
- 13 Sept 2026
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- Friedhelm Hummel
- Diseases
- Stroke
- NCT number
- NCT07792811
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 84
- From 13 Sept 2026 to the primary completion date, 31 Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Regular use of narcotic drugs or abusive alcohol consumption
Other illness
- Unable to provide informed consent due to cognitive, psychiatric, or medical conditions impairing decision-making capacity
- Severe neuropsychiatric (e.g., major depression, schizophrenia) or medical disease (e.g., progressive cancer, unstable systemic disease, neurodegenerative disease)
- Contraindications for NIBS or MRI
- Electronic or ferromagnetic medical implants/device, non-MRI compatible metal implant, b. Fully or partially implanted conductive objects i. Passive implants: stents, orthopedic/orthodontic implants, screws, shunts, etc.
- Active implants: cochlear implants, deep brain stimulation leads and electrodes, fully implanted brain monitoring devices iii. Partially implanted devices: monitoring electrodes (e.g., stereoelectroencephalography, electrocortigraphy, etc.
- Surface-mounted conductive objects: conductive low-impedance structure mounted to the skin that may introduce shortcuts.
- History of seizures d. Medication that significantly interacts with NIBS being benzodiazepines, tricyclic antidepressants and antipsychotics.
- Non-intact skin where electrodes are intended ot be placed
Other
- Severe cognitive, sensory or musculoskeletal dysfunctions prohibiting to understand instructions or to perform the rehabilitative tasks
- Pregnancy
- Integral and bilateral lesion of the striatum
- Concomittant participation in another clinical trial
- Active request of not being informed in case of incidental findings
Who the study is looking for
- Informed Consent signed by the participant
- Age ≥ 18 years old
- First ever ischemic stroke with motor impairment
- Stroke incident ≥ 12 weeks at consent
- Moderate to severe motor impairment (Fugl-Meyer Assessment (FMA) \>20 and \<58)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CRR SUVA Coordinator of this site? Confirm its status | Sion | Switzerland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.