NCT07794774Not yet recruitingPhase 3
A Study to Learn About Safety and Effects of Once-monthly Treatment With Berobenatide in Adults With Obesity Disease in Japan (VESPER-JM)
A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF ONCE-MONTHLY BEROBENATIDE IN ADULTS WITH OBESITY DISEASE IN JAPAN (VESPER-JM)
Source: ClinicalTrials.gov · Last updated 25 Sept 2026
Brief summary (registry, in English)
The purpose of this clinical study is to learn about safety and effects of berobenatide (PF-08653944) in adults with obesity disease, a condition in which a person has too much body fat, which can harm their health and increase the risk of other medical problems. Some participants in this study may also have type 2 diabetes, a condition in which the body does not use insulin properly, causing blood sugar levels to become too high. This study is seeking participants in Japan who: * Have obesity disease. * May have type 2 diabetes. * Meet the study-specific age, weight, and health requirements. About 197 adults will take part in this study. Participants will be randomly assigned to receive either berobenatide or a placebo. A placebo looks like the study medicine but does not contain any active medicine. Berobenatide or placebo will be given as an injection under the skin of the abdomen (belly area). The study will compare the experiences of people receiving berobenatide with those receiving placebo to determine whether berobenatide can help people lose weight. The study will also assess the safety of berobenatide and its effects on body weight and other health measures. People will take part in this study for about 21 months. During this time, they will have about 16 study visits at the site. They will also have 2 study visits over the phone.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 197 (estimated)
- First submitted
- 26 Aug 2026
- Start date
- Sept 2026
- Primary completion date
- Feb 2029
- Lead sponsor
- Pfizer
- Diseases
- Obesity
- NCT number
- NCT07794774
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 197
- From Sept 2026 to the primary completion date, Feb 2029
- 28 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have a self-reported body weight change greater than 5% within 90 days prior to Screening.
Other illness
- Diagnosis of type 1 diabetes or any other form of diabetes other than T2D.
- History of acute or chronic pancreatitis.
- Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).
Who the study is looking for
- Aged ≥18 years.
- BMI of: ≥27.0 kg/m2 to \<35.0 kg/m2 with ≥2 obesity-related health disorders or BMI of ≥35.0 kg/m2 with ≥1 obesity-related health disorder. The participant must have at least one of either hypertension, dyslipidemia or glucose intolerance (T2D and impaired glucose tolerance etc.) as an obesity-related health disorder.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (28)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yamasaki Family Clinic Coordinator of this site? Confirm its status | Amagasaki | Japan | Unknown status |
| Tokyo Center Clinic Coordinator of this site? Confirm its status | Chuo-ku | Japan | Unknown status |
| Tokyo-Eki Center-building Clinic Coordinator of this site? Confirm its status | Chuo-ku | Japan | Unknown status |
| Tokyo Asbo Clinic Coordinator of this site? Confirm its status | Chuo-ku | Japan | Unknown status |
| AIC Yaesu Clinic Coordinator of this site? Confirm its status | Chuo-ku | Japan | Unknown status |
| Fukuwa Clinic Coordinator of this site? Confirm its status | Chuo-ku | Japan | Unknown status |
| Medical Corporation Boocs Boocs Clinic Fukuoka Coordinator of this site? Confirm its status | Fukuoka | Japan | Unknown status |
| Tenjin Sogo Clinic Coordinator of this site? Confirm its status | Fukuoka | Japan | Unknown status |
| Keikokai Medical Corporation P-one Clinic Coordinator of this site? Confirm its status | Hachiōji | Japan | Unknown status |
| Medical Corp Seikoukai New Medical Research System Clinic Coordinator of this site? Confirm its status | Hachioji-shi | Japan | Unknown status |
| Hachioji Clinic Shincho Coordinator of this site? Confirm its status | Hachioji-shi | Japan | Unknown status |
| Oishi Clinic Coordinator of this site? Confirm its status | Kasuya-gun | Japan | Unknown status |
| Patient First Clinic Ginza-Shimbashi Coordinator of this site? Confirm its status | Minato-ku | Japan | Unknown status |
| Yokoi Clinic Coordinator of this site? Confirm its status | Minoh | Japan | Unknown status |
| Minami Akatsuka Clinic Coordinator of this site? Confirm its status | Mito | Japan | Unknown status |
| Nishiyamado Keiwa Hospital Coordinator of this site? Confirm its status | Naka | Japan | Unknown status |
| Shimamura Memorial Hospital Coordinator of this site? Confirm its status | Nerima-ku | Japan | Unknown status |
| Kanemura Clinic Coordinator of this site? Confirm its status | Osaka-shi Ikuno-ku | Japan | Unknown status |
| Manda Memorial Hospital Coordinator of this site? Confirm its status | Sapporo | Japan | Unknown status |
| Medical Corporation Heishinkai ToCROM Clinic Coordinator of this site? Confirm its status | Shinjuku-ku | Japan | Unknown status |
| Higashi-Shinjuku Clinic, Keikokai Medical Corp. Coordinator of this site? Confirm its status | Shinjuku-ku | Japan | Unknown status |
| Seeds Clinic Shinjuku-Sanchome, Eijinkai Medical Corporation Coordinator of this site? Confirm its status | Shinjuku-ku | Japan | Unknown status |
| Soka Sugiura Internal medicine Clinic Coordinator of this site? Confirm its status | Soka-shi | Japan | Unknown status |
| Medical Corporation Heishinkai OCROM Clinic Coordinator of this site? Confirm its status | Suita | Japan | Unknown status |
| Nihonbashi Sakura Clinic Coordinator of this site? Confirm its status | Tokyo | Japan | Unknown status |
| Ikebukuro Metropolitan Clinic Coordinator of this site? Confirm its status | Toshima-ku | Japan | Unknown status |
| MI Clinic, Medical Corporation Jinsenkai Coordinator of this site? Confirm its status | Toyonaka-shi | Japan | Unknown status |
| Medical Corporation Hitomikai Motomachi Takatsuka Naika Clinic Coordinator of this site? Confirm its status | Yokohama | Japan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.