NCT07796750Completed
Extensive BITA Grafting in the Canary Islands: an IPTW Analysis
Implementing a CABG Program Based on Extensive Bilateral Internal Thoracic Artery Use in the Canary Islands: an Inverse Probability of Treatment Weighted Analysis of Survival, Stroke and Sternal Wound Complications
Source: ClinicalTrials.gov · Last updated 1 Sept 2026
Brief summary (registry, in English)
Coronary artery bypass grafting (CABG) remains the preferred revascularization strategy for patients with complex multivessel coronary artery disease. The left internal thoracic artery is universally accepted as the standard conduit for grafting the left anterior descending artery, but the long-term clinical benefit and safety of bilateral internal thoracic artery (BITA) grafting compared with single internal thoracic artery (SITA) grafting remain debated. This retrospective cohort study compares long-term outcomes after BITA versus SITA grafting in consecutive adult patients undergoing first-time isolated CABG with at least two coronary grafts between May 1, 2017 and October 31, 2025 at Hospital Universitario de Gran Canaria Dr. Negrin. The primary endpoint is all-cause mortality during follow-up. Secondary outcomes include cardiovascular mortality, non-cardiovascular mortality, deep sternal wound infection, stroke, myocardial infarction, repeat coronary revascularization, and major adverse cardiovascular events (MACE). Treatment groups will be balanced using stabilized inverse probability of treatment weighting derived from a multivariable propensity score model including clinically relevant baseline variables. Long-term outcomes will be analyzed using weighted Kaplan-Meier survival curves and Cox proportional hazards regression.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 666 (actual)
- First submitted
- 24 Aug 2026
- Start date
- Jan 2024
- Primary completion date
- May 2026
- Lead sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
- Diseases
- Coronary artery disease, Stroke
- NCT number
- NCT07796750
What you commit to
- Study type: Observational
- Participants enrolled: 666
- From Jan 2024 to the primary completion date, May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous coronary artery bypass grafting.
- Concomitant cardiac surgical procedures.
Other
- Single coronary artery graft only.
- Missing information regarding arterial grafting strategy.
- Missing follow-up data.
- Missing essential baseline variables preventing propensity score estimation.
Who the study is looking for
- Age 18 years or older.
- First-time isolated coronary artery bypass grafting.
- At least two coronary artery grafts performed.
- Surgery performed between May 1, 2017 and October 31, 2025.
- Complete information regarding surgical grafting strategy.
- Available follow-up.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitario de Gran Canaria Dr Negrín Coordinator of this site? Confirm its status | Las Palmas de Gran Canaria | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.