NCT07800741Not yet recruiting
Flow-Controlled vs. Pressure-Controlled Ventilation in CABG: Effects on Lung Aeration and Diaphragm Function
Comparison of Flow-Controlled Ventilation and Pressure-Controlled Ventilation on Lung Aeration and Diaphragm Function in Patients Undergoing Elective Isolated On-Pump Coronary Artery Bypass Graft Surgery: A Single-Centre Prospective Randomised Controlled Trial
Source: ClinicalTrials.gov · Last updated 2 Sept 2026
Brief summary (registry, in English)
Pulmonary atelectasis and loss of lung aeration are common complications following cardiac surgery with cardiopulmonary bypass (CPB) and are associated with impaired oxygenation and prolonged mechanical ventilation. Diaphragm dysfunction occurring in the perioperative period may further delay extubation and prolong intensive care unit (ICU) stay. Flow-Controlled Ventilation (FCV) is a novel ventilation modality that provides continuous, flow-based delivery of tidal breaths with a triangular flow profile, potentially offering superior dynamic compliance optimisation compared to conventional Pressure-Controlled Ventilation (PCV).
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 154 (estimated)
- First submitted
- 30 Aug 2026
- Start date
- 30 Sept 2026
- Primary completion date
- 30 Sept 2028
- Lead sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT07800741
What you commit to
- Study type: Interventional
- Planned participants: 154
- From 30 Sept 2026 to the primary completion date, 30 Sept 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Emergency surgery
- Combined surgical procedures (e.g., valve repair/replacement + CABG)
- Severe COPD exacerbation or active pneumonia at time of surgery
- Inability to obtain standard lung or diaphragm ultrasound images due to pleural effusion, thoracic deformity, or prior thoracic surgery
Other illness
- Known diaphragm paralysis or neuromuscular disease
Other
- Preoperative requirement for invasive or non-invasive mechanical ventilation
- Body mass index ≥40 kg/m²
Who the study is looking for
- Age ≥18 years
- Planned elective isolated on-pump coronary artery bypass graft (CABG) surgery
- ASA Physical Status Classification II-IV
- Written informed consent obtained
- Technically adequate acoustic window for lung and diaphragm ultrasonography
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kosuyolu Heart Training and Research Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.