NCT07800988Not yet recruiting
Vitis Intervention Trial in Substrate Metabolism
Acute Modulatory Role of Whole Grape Polyphenols on Room Calorimetry Derived Respiratory Exchange Ratio and Mitochondrial Function in Obesity
Source: ClinicalTrials.gov · Last updated 2 Sept 2026
Brief summary (registry, in English)
Obesity is associated with reduced metabolic flexibility (MetFlex), the capacity to shift between carbohydrate and lipid oxidation in response to nutrient availability. Grape polyphenols (resveratrol, catechins, quercetin, epicatechin) enhance fat oxidation and mitochondrial function in laboratory and animal studies, but whole grapes, rather than purified extracts, have not been tested for acute effects on MetFlex measured directly by whole-room calorimetry paired with mitochondrial function. This study integrates whole-room indirect calorimetry with high-resolution respirometry in peripheral blood mononuclear cells (PBMCs) to determine whether whole grape polyphenols shift the postprandial respiratory exchange ratio (RER) response to a high-fat meal and alter mitochondrial respiration, and whether responses differ by adiposity phenotype (lean vs. overweight/obesity).
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 18 Aug 2026
- Start date
- Sept 2026
- Primary completion date
- Jul 2027
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Obesity
- NCT number
- NCT07800988
What you commit to
- Study type: Interventional
- Planned participants: 20
- From Sept 2026 to the primary completion date, Jul 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current smoking; drug or alcohol abuse
- Hormone replacement therapy or medications known to affect metabolism
- Current or prior bulimia nervosa, binge eating disorder, or anorexia nervosa
Other illness
- Claustrophobia or psychiatric conditions that would make a 40-hour confined stay especially distressing or harmful
- Grape allergy, or food allergies/intolerances precluding use of the metabolic kitchen
- Any condition that, in the PI's opinion, would make participation unsafe or could interfere with conduct/interpretation of the study
Other
- Weight instability, recent/active weight-loss attempts, or structured exercise initiation during the study
- Pregnant or breastfeeding
Who the study is looking for
- Men and women aged 25-60 years
- BMI 18-24.9 kg/m² (lean phenotype, n=10) or BMI 25-40 kg/m² (overweight/obesity phenotype, n=10)
- Low habitual grape consumption
- Weight stable (no change \>5% in prior 6 months) and not actively attempting weight change
- White blood cell count within normal limits
Age in the registry: 25 years to 60 years · Sex: All · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.