NCT07802275Completed
Postprandial Glucose Kinetics After Carbohydrate Restriction
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
The goal of this study is to test whether a low-carbohydrate diet (LCD), comparred with a Mediterranean diet (MED) producing similar weight loss, differentially affects fasting and postprandial glucose metabolism in individuals with overweight and dysglycemia. The main questions it aims to answer are: * Is oral glucose absorption delayed or reduced after chronic carbohydrate restriction? * Is insulin sensitivity differentially affected? Participants will follow 4 weeks of LCD and 4 weeks of MED, in a random order, separated by a 4-week washout. After each intervention, participants will undergo a dual-tracer 75-g oral glucose tolerance test.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 29 (actual)
- First submitted
- 31 Aug 2026
- Start date
- 1 Nov 2019
- Primary completion date
- 30 Mar 2024
- Lead sponsor
- Azienda Ospedaliero, Universitaria Pisana
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT07802275
What you commit to
- Study type: Interventional
- Participants enrolled: 29
- From 1 Nov 2019 to the primary completion date, 30 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medications known to interfere with carbohydrate metabolism or intestinal nutrient absorption
- Metabolic surgery
Other illness
- Diabetes mellitus
- Chronic kidney disease
- Heart failure
- Severe liver disease
Who the study is looking for
- both females and males
- age 18-65 years
- BMI 25-40 kg/m2
- impaired glucose regulation (defined as fasting plasma glucose 5.6-6.9 mmol/L, 1-h plasma glucose ≥8.6 mmol/L, 2-h plasma glucose 7.8-11.0 mmol/L, or HbA1c 39-47 mmol/mol)
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Laboratory of Metabolism, Nutrition and Atherosclerosis, University of Pisa Coordinator of this site? Confirm its status | Pisa | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.