NCT07804654Completed
Protocolised Natriuresis-Guided Decongestion at Different Diuretic Intensities in Acute Heart Failure
Protocolised Decongestive Strategies With Natriuretic Guidance in Acute Heart Failure - Results of The 'DESTINaTE-AHF' Pilot Randomised Controlled Trial
Source: ClinicalTrials.gov · Last updated 4 Sept 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn how different doses of a water-removing medicine (diuretic) work in adults admitted to hospital with acute heart failure. It will also assess the safety of these treatment approaches. The main questions this study aims to answer are: Does starting with a higher or lower dose of diuretic affect how much sodium and urine the body removes during the first 24 hours? Are there differences in side effects or short-term health outcomes between the treatment approaches? Researchers will compare two treatment approaches that use urine sodium and urine output to guide diuretic treatment with standard care. Participants will receive intravenous diuretic treatment and have their urine sodium, urine output, symptoms, blood tests, and clinical outcomes assessed.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 109 (actual)
- First submitted
- 27 Aug 2026
- Start date
- 1 Jan 2026
- Primary completion date
- 1 Jul 2026
- Lead sponsor
- Universiti Teknologi Mara
- Diseases
- Heart failure
- NCT number
- NCT07804654
What you commit to
- Study type: Interventional
- Participants enrolled: 109
- From 1 Jan 2026 to the primary completion date, 1 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Requirement or anticipated requirement for renal replacement therapy
Other illness
- End-stage renal disease requiring chronic dialysis
- Known hypersensitivity to furosemide
Other
- Requirement or anticipated requirement for invasive mechanical ventilation
- Requirement or anticipated requirement for inotropic or vasopressor support
- Cardiogenic shock or systolic blood pressure below 100 mmHg
- Pregnancy or breastfeeding
Who the study is looking for
- Age 18 years or older
- Malaysian nationality
- Hospitalised with acute heart failure, either de novo acute heart failure or acute decompensated chronic heart failure
- Clinical evidence of congestion requiring intravenous loop diuretic therapy, with at least one of the following: peripheral oedema, orthopnoea, paroxysmal nocturnal dyspnoea, pulmonary crepitations, elevated jugular venous pressure, ascites, or congestive hepatomegaly
- Able to provide informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Al-Sultan Abdullah, Universiti Teknologi MARA Coordinator of this site? Confirm its status | Shah Alam | Malaysia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.