NCT07805161Completed
Bipolar RFA Versus Phenol Neurolysis for Knee Osteoarthritis Pain
Observational Comparative Study on the Analgesic Outcomes of Bipolar Radiofrequency Ablation Versus Phenol Neurolysis of the Genicular Nerves in Gonarthrosis
Source: ClinicalTrials.gov · Last updated 4 Sept 2026
Brief summary (registry, in English)
This prospective observational comparative study evaluates the analgesic efficacy and safety of ultrasound-guided bipolar radiofrequency ablation (BPRFA) versus phenol chemical neurolysis (PCN) of the genicular nerves in patients with chronic knee osteoarthritis (gonarthrosis) refractory to conservative treatment. Patients with moderate-to-severe chronic knee pain who demonstrate significant pain relief following diagnostic genicular nerve block undergo either BPRFA or PCN targeting the superior medial, superior lateral, and inferior medial genicular nerves under ultrasound guidance. Pain intensity and functional outcomes are assessed using the Numeric Rating Scale (NRS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at baseline and during follow-up evaluations at 4, 12, and 24 weeks after treatment. The study aims to compare pain reduction, functional improvement, responder rates, and procedure-related adverse events between the two treatment modalities.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 69 (actual)
- First submitted
- 5 May 2026
- Start date
- Aug 2024
- Primary completion date
- Jun 2025
- Lead sponsor
- Saglik Bilimleri Universitesi
- NCT number
- NCT07805161
What you commit to
- Study type: Interventional
- Participants enrolled: 69
- From Aug 2024 to the primary completion date, Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous knee surgery
- Current use of antiplatelet or anticoagulant therapy
- Intra-articular injection or interventional knee procedure within the previous 6 months
Other illness
- Knee pain due to causes other than osteoarthritis, such as fracture, trauma, spinal disorder, or inflammatory arthritis
- Cognitive impairment
- Hepatic or renal failure
- Severe psychiatric disorder
- Local or systemic infection
Other
- Knee joint effusion detected on physical examination or ultrasound
- Coagulopathy
- Presence of a pacemaker
Who the study is looking for
- Adults aged 18 to 75 years
- Unilateral moderate-to-severe knee pain due to gonarthrosis
- Numeric Rating Scale (NRS) score ≥6
- Knee pain lasting longer than 6 months
- Radiological diagnosis of knee osteoarthritis, Kellgren-Lawrence grade 2-4
- Failure of conservative treatments, including analgesic medications, physical therapy, or intra-articular injections
- At least 50% pain relief after diagnostic genicular nerve block
- Ability to provide written informed consent
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Of Health Sciences, Gulhane School Of Medicine, Department Of Algology Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.