NCT07805967Recruiting
Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)
Source: ClinicalTrials.gov · Last updated 8 Sept 2026
Brief summary (registry, in English)
This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 20 Nov 2025
- Start date
- 12 Nov 2025
- Primary completion date
- 31 Aug 2030
- Lead sponsor
- Second Affiliated Hospital of Soochow University
- Diseases
- Lewy body dementia
- NCT number
- NCT07805967
What you commit to
- Study type: Observational
- Planned participants: 500
- From 12 Nov 2025 to the primary completion date, 31 Aug 2030
- 20 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure .
- Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .
Who the study is looking for
- MSA : Meets the "probable MSA" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) .
- DLB : Meets "probable DLB" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) .
- PSP : Meets "probable PSP-Richardson syndrome" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years .
- CBD : Meets "probable CBD" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia/dystonia/alien limb).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (20)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Changshu Hospital Affiliated to Nanjing University of Chinese Medicine Coordinator of this site? Confirm its status | Changshu | China | Recruiting |
| Deyang People's Hospital Coordinator of this site? Confirm its status | Deyang | China | Not yet recruiting |
| The Second People's Hospital of Huai'an Coordinator of this site? Confirm its status | Huai'an | China | Not yet recruiting |
| Changxing people' s hospital Coordinator of this site? Confirm its status | Huzhou | China | Not yet recruiting |
| Jiaxing Second Hospital Coordinator of this site? Confirm its status | Jiaxing | China | Not yet recruiting |
| The First People's Hospial of Kunshan Coordinator of this site? Confirm its status | Kunshan | China | Not yet recruiting |
| Mianyang 404 Hospital Coordinator of this site? Confirm its status | Mianyang | China | Not yet recruiting |
| Jiangsu Province Official Hospital Coordinator of this site? Confirm its status | Nanjing | China | Not yet recruiting |
| Affiliated Hospital of Nantong University Coordinator of this site? Confirm its status | Nantong | China | Not yet recruiting |
| The Second Affiliated Hospital of Nantong University Coordinator of this site? Confirm its status | Nantong | China | Not yet recruiting |
| Jiangsu Province （Suqian）Hospital Coordinator of this site? Confirm its status | Suqian | China | Recruiting |
| The Forth Affiliated Hospital of Soochow University Coordinator of this site? Confirm its status | Suzhou | China | Recruiting |
| The Second Affiliated Hospital of Soochow University Coordinator of this site? Confirm its status | Suzhou | China | Recruiting |
| The affiliated hospital of xuzhou medical university Coordinator of this site? Confirm its status | Xuzhou | China | Not yet recruiting |
| The Second Affiliated Hospital of Xuzhou Medical University Coordinator of this site? Confirm its status | Xuzhou | China | Not yet recruiting |
| Yancheng Third People's Hospital Coordinator of this site? Confirm its status | Yancheng | China | Recruiting |
| Affiliated Hospital of Yangzhou University Coordinator of this site? Confirm its status | Yangzhou | China | Not yet recruiting |
| Yantai Yuhuangding Hospital Coordinator of this site? Confirm its status | Yantai | China | Not yet recruiting |
| Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine/Zhangjiagang Traditional Chinese Medicine Hospital Coordinator of this site? Confirm its status | Zhangjiagang | China | Not yet recruiting |
| The Forth People's Hospital of Zhenjiang Coordinator of this site? Confirm its status | Zhenjiang | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.