NCT07807696Recruiting
Olive Oil Before Lung Cancer Surgery to Prevent Chylothorax
A Multicenter, Prospective, Randomized Controlled Trial of Preoperative Oral Olive Oil for the Prevention of Postoperative Chylothorax in Patients With Lung Cancer
Source: ClinicalTrials.gov · Last updated 8 Sept 2026
Brief summary (registry, in English)
Chylothorax is a rare but serious complication after lung cancer surgery and mediastinal lymph node dissection. This multicenter randomized trial will evaluate whether drinking 40 mL of extra-virgin olive oil 4 hours before surgery can reduce the occurrence of chylothorax after curative lung cancer resection. A total of 1,036 adults with resectable lung cancer will be assigned in a 1:1 ratio to preoperative oral olive oil or standard preoperative fasting without additional olive oil. The primary outcome is the occurrence of chylothorax within 30 days after surgery. Secondary outcomes include repeat surgery, postoperative complications, chest drainage, length of chest tube use, length of hospital stay, and the safety and tolerability of the intervention.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1036 (estimated)
- First submitted
- 31 Aug 2026
- Start date
- 15 Mar 2026
- Primary completion date
- 1 Jun 2027
- Lead sponsor
- Fudan University
- Diseases
- Lung cancer
- NCT number
- NCT07807696
What you commit to
- Study type: Interventional
- Planned participants: 1036
- From 15 Mar 2026 to the primary completion date, 1 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior ipsilateral thoracic surgery or thoracic radiotherapy or chemotherapy.
Other illness
- Allergy to olive oil or any of its components.
- History of acute or chronic pancreatitis or severe biliary disease.
- Fat malabsorption syndrome.
Other
- Unable to comply with preoperative dietary instructions.
Who the study is looking for
- Voluntary participation and willing and able to complete all study procedures.
- Age 18 to 80 years, inclusive, at informed consent.
- Eastern Cooperative Oncology Group performance status of 0 or 1.
- Resectable lung cancer.
- No prior surgery for lung cancer.
- Treatment-naive and no prior radiotherapy or chemotherapy.
- Able to take food orally before surgery.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fudan University Shanghai Cancer Center Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.