NCT07807995Enrolling by invitationPhase 3
A Phase 3 Open-Label Study of Long-term Treatment With Povetacicept in Adults With Immunoglobulin A Nephropathy
A Phase 3, Single-Arm, Open-Label Extension Study Evaluating the Long-Term Safety and Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the long-term safety, tolerability and efficacy of povetacicept in participants with immunoglobulin A nephropathy (IgAN).
- Status (registry)
- Enrolling by invitation
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 605 (estimated)
- First submitted
- 20 Aug 2026
- Start date
- 17 Sept 2026
- Primary completion date
- 28 Dec 2029
- Lead sponsor
- Vertex Pharmaceuticals Incorporated
- Diseases
- IgA nephropathy
- NCT number
- NCT07807995
- EU CT number
- 2025-525064-14-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 605
- From 17 Sept 2026 to the primary completion date, 28 Dec 2029
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- \- Planned participation in another interventional, therapeutic clinical trial (other than the parent study).
- Other protocol defined Inclusion/Exclusion criteria may apply.
Who the study is looking for
- Completed the Week 104 visit in the parent study VX24-AIS-D08 (NCT06564142) and has not permanently discontinued study drug
- Estimated glomerular filtration rate (eGFR) greater than or equal to (≥) 15 milliliters per minute (mL/min)/1.73 square meter (m\^2) within 45 days of Day 1 of this study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Western Nephrology - Arvada Coordinator of this site? Confirm its status | Arvada | United States | Unknown status |
| Prolato Clinical Research Center - Kirby Dr Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Idaho Kidney Institute- Idaho Falls Coordinator of this site? Confirm its status | Idaho Falls | United States | Unknown status |
| CTR Oakwater, LLC Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.