NCT07810517Recruiting
Lactobacillus Acidophilus and Inulin for Cognitive Impairment in Obesity
Effect of Lactobacillus Acidophilus Combined With Inulin on Cognitive Impairment in Patients With Obesity
Source: ClinicalTrials.gov · Last updated 10 Sept 2026
Brief summary (registry, in English)
This randomized crossover clinical trial aims to evaluate the effect of a synbiotic containing Lactobacillus acidophilus and inulin on cognitive function in adults with obesity and mild cognitive impairment. Forty participants aged 30-40 years will be randomly assigned to two groups. Participants will receive either the synbiotic intervention or a control preparation, followed by crossover to the alternate intervention. Cognitive function will be evaluated using the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and Memory Alteration Test (M@T). Fecal butyrate and Lactobacillus acidophilus, as well as serum inflammatory cytokines and BDNF, will also be assessed to explore potential mechanisms involving the gut-brain axis.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 3 Sept 2026
- Start date
- 1 Nov 2026
- Primary completion date
- 2 Feb 2027
- Lead sponsor
- Anahuac University
- Diseases
- Obesity
- NCT number
- NCT07810517
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Nov 2026 to the primary completion date, 2 Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Antibiotic use during the 3 months prior to treatment.
Other illness
- Advanced cognitive impairment.
- Diseases associated with cognitive impairment, including Alzheimer's disease, cerebral ischemia, cerebrovascular events, severe traumatic brain injury, or motor deficits.
- Allergy to almonds or any component of the synbiotic or vehicle.
- Diagnosed gastrointestinal disorders, including irritable bowel syndrome or inflammatory bowel disease, that could influence study outcomes.
- Diagnosis of type 2 diabetes mellitus.
Other
- Consumption of probiotics or supplements and/or frequent intake of high-fiber or fermented foods.
Who the study is looking for
- Adults aged 30 to 40 years.
- Diagnosis of obesity for more than 10 years.
- Presence of mild cognitive impairment, evaluated using cognitive assessment scales.
- BMI ≥30 kg/m².
- Body fat percentage ≥35% in women and ≥25% in men.
- Willingness to participate and provide written informed consent.
Age in the registry: 30 years to 40 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universidad Anahuac Coordinator of this site? Confirm its status | Huixquilucan | Mexico | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.