NCT07810712Completed
PNS Motor Stimulation Study
Determination of Efficacy of Sustained Motor Contraction Generated Using StimWave Peripheral Nerve Stimulator
Source: ClinicalTrials.gov · Last updated 29 Sept 2026
Brief summary (registry, in English)
Paralysis is one of the most disabling features of Spinal cord injury and stroke. In select cases, where the nerve is intact, stimulation can achieve meaningful muscle contraction e.g. to restore grip and release function. Previously, products to serve this purpose had been developed and successfully implanted (Freehand device). However, they had technical and cost limitations and have gone out of production. The investigators aim to investigate if a simple implantable and commercially available system could replicate the same function. Patients implanted with a wireless peripheral nerve stimulation (PNS) system for chronic pain in the upper limb shall be identified and approached for consent. Surface electromyography (EMG, baseline and with active contraction) shall be performed to confirm intact motor nerves. Baseline MRC (Medical Research Council Scale for Muscle Strength) grade shall be assessed. PNS shall be programmed to produce muscle contraction (within FDA approved safe limits for the device) with the EMG monitoring. The muscle contraction shall be recorded on video for further evaluation. Strength of contraction shall be assessed on the MRC scale. Stimulation parameters shall be then re-adjusted to pain-relief setting. Neurological examination shall be performed and return to baseline EMG ascertained. Data shall be analysed and the Study shall end when the data for the last participant is gathered.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 4 (actual)
- First submitted
- 3 Sept 2026
- Start date
- 1 Feb 2023
- Primary completion date
- 6 Aug 2024
- Lead sponsor
- Walton Centre NHS Foundation Trust
- Diseases
- Stroke
- NCT number
- NCT07810712
What you commit to
- Study type: Interventional
- Participants enrolled: 4
- From 1 Feb 2023 to the primary completion date, 6 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Myopathy and other LMN disorders;
Age
- Age \<18yr;
Other
- Impaired LMN pathway determined by EMG.
Who the study is looking for
- Male or Female, aged 18 years or above with implanted Curonix (formerly: Stimwave) PNS for radial, ulnar or median nerve;
- Functioning lower motor neuron (LMN) pathway determined by baseline EMG.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Walton Centre NHS Foundation Trust Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.