NCT07811518RecruitingPhase 4
Latent Infection Freshmen Tracking for Tuberculosis
Real-World Implementation and Effectiveness of Tuberculosis Preventive Treatment in School Health Services in China
Source: ClinicalTrials.gov · Last updated 10 Sept 2026
Brief summary (registry, in English)
The goal of this study is to learn whether taking short-course preventive treatment in high school and college freshmen with strong positive tuberculosis (TB) skin tests can safely and effectively protect them from developing active TB over a 3-to-4-years period. Main question: Does taking short-course preventive treatment reduce the risk of active TB in freshmen who have strong positive TB skin tests? All freshmen across 26 schools in Meishan City, Sichuan Province, China were screened for TB. Among them, the students with strong positive skin tests (indicating latent TB infection) and no active disease entered the study. Students voluntarily chose to either take a 3-month short-course preventive treatment under campus medical supervision or receive routine health observation without medication. Researchers tracked all participants for 3 to 4 years to monitor who developed active TB and evaluate the treatment's safety and effectiveness.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 3000 (estimated)
- First submitted
- 4 Sept 2026
- Start date
- 15 Aug 2022
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- Affiliated Hospital of Nantong University
- Diseases
- Tuberculosis
- NCT number
- NCT07811518
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 3000
- From 15 Aug 2022 to the primary completion date, 31 Aug 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Presence of active TB at baseline screening
- Voluntary receipt of Vaccae vaccination (for the target cohort)
Who the study is looking for
- Matriculating freshmen aged 14-24 years enrolled across 26 participating educational institutions
- Completion of baseline tuberculosis screening, including systematic symptom screening, digital chest radiography, and tuberculin skin test (TST)
- Target cohort requirement: TST strong reactivity (induration ≥15 mm or severe local reactions such as blisters, necrosis, or lymphangitis) with active TB ruled out at baseline
- Control cohort requirement: TST induration \<15 mm (including negative \<5 mm, weakly positive 5-9 mm, and moderately positive 10-14 mm)
Age in the registry: 14 years to 24 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Meishan Municipal Center for Disease Prevention and Control Coordinator of this site? Confirm its status | Meishan | China | Recruiting |
| Affiliated Hospital of Nantong University Coordinator of this site? Confirm its status | Nantong | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.