NCT07813923Not yet recruiting
Citrus Sinensis Peel Gel for Radiation-Induced Oral Mucositis
The Effect of Citrus Sinensis Peel Gel on Radiation-induced Oral Mucositis in Head and Neck Cancer Patients (Randomized Controlled Clinical Trial)
Source: ClinicalTrials.gov · Last updated 16 Sept 2026
Brief summary (registry, in English)
This randomized controlled clinical trial aims to evaluate the efficacy of Citrus sinensis peel extract gel in the treatment of radiation-induced oral mucositis in head and neck cancer patients. Thirty adult patients with head and neck cancer who develop oral mucositis during radiotherapy will be randomly allocated into two parallel groups. The intervention group will receive Citrus sinensis peel extract gel, while the control group will receive conventional supportive treatment. Clinical outcomes will be evaluated at baseline, 3 weeks, and 6 weeks, including pain intensity and severity of oral mucositis. Salivary total antioxidant capacity will be assessed at baseline and after 6 weeks.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 6 Sept 2026
- Start date
- 1 Oct 2026
- Primary completion date
- 1 Feb 2027
- Lead sponsor
- Alexandria University
- Diseases
- Head and neck cancer
- NCT number
- NCT07813923
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Oct 2026 to the primary completion date, 1 Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients allergic to orange
- Patients allergic to citrus peel or gel formulation components
- Patients with systemic diseases (e.g., hypertension, diabetes, cardic diseases etc.)
Other
- Smokers, due to impaired mucosal healing and increased inflammation
- Pregnant and lactating women
- Patients with poor oral hygiene
- Use of systemic or topical mucositis treatments within the past 7 days
- Patients who have other oral lesions not related to mucositis (e.g., herpetic ulcers, candidiasis)
Who the study is looking for
- Patients undergoing radiotherapy for head and neck cancer as postoperative (adjuvant) therapy or definitive therapy.
- Patients between 18-50 years.
- Both males and females.
- Patients whose radiotherapy treatment planned dose is 50 Gy or above 8
- Patients receiving radiotherapy alone or receiving concomitant cisplatin (or carboplatin) with radiotherapy.
- Patients who are clinically diagnosed with oral mucositis (WHO grade ≥1).
Age in the registry: 18 years to 50 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| outpatient clinic of the Department of Clinical Oncology, Faculty of Medicine Coordinator of this site? Confirm its status | Alexandria | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.