Metabolic and Nutritional Responses to Acute High-intensity Interval Exercise Performed Under Hypoxic vs. Normoxic Conditions at Matched External Workload in Adults With Overweight and Obesity.

Brief summary (registry, in English)

Obesity management involves lifestyle and dietary measures that include appropriate nutrition and increased physical activity (PA). Among the various PA options available, HIIT (High-Intensity Interval Training) workouts are now recognized as fun and effective programs for promoting fat loss. To date, in overweight or obese individuals, only two studies mention the benefits of HIIT performed under hypoxia for modulating body composition, and more specifically, reducing the amount of adipose tissue. These studies hypothesize an increased energy expenditure under hypoxia associated with a transient loss of appetite. In order, to further investigate the adaptations following HIIT under hypoxia versus normoxia, we propose to compare, in acute conditions, two HIIT sessions (simulated hypoxia-normobaric vs. normoxia) in overweight or obese subjects. The objective of this assessment is to compare, during exercise and recovery (+2h), oxygen consumption, corresponding energy expenditure, and carbohydrate and lipid utilization in hypoxic versus normoxic conditions. Given the potential influence of hypoxia on appetite, spontaneous food intake and energy expenditure post-24h will also be measured. Finally, since pleasure and perceived exertion are key parameters in adherence to an adapted physical activity (APA) program, these two concepts will also be evaluated through the subjects' experiences.

What you commit to

• Study type: Interventional
• Participants enrolled: 18
• From Nov 2024 to the primary completion date, Sept 2026
• 1 site in 1 country
• Visits and tests: ask the trial team, the registry does not list them

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Who cannot take part

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Who the study is looking for

Age in the registry: 50 years to 70 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

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