NCT07816900Completed
Efficacy and Safety of Da-Cheng-Qi Decoction in Severe Acute Pancreatitis
Efficacy and Safety of Da-Cheng-Qi Decoction in the Acute Stage of Severe Acute Pancreatitis: a Single-Center, Prospective, Randomized, Controlled Trial
Source: ClinicalTrials.gov · Last updated 24 Sept 2026
Brief summary (registry, in English)
This single-center prospective randomized controlled trial evaluated Da-Cheng-Qi Decoction (DCQD) as the acute-stage intervention of an integrated traditional Chinese and Western medicine whole-stage treatment protocol for severe acute pancreatitis (SAP). Sixty adults with SAP and intra-abdominal hypertension (IAP ≥ 12 mmHg) were randomized within 72 h of onset to receive standard Western treatment plus DCQD (100 mL via nasogastric tube twice daily for 7 days) or standard Western treatment alone. The primary outcome was intra-abdominal pressure measured by standardized bladder manometry every 12 h for 7 days. Secondary outcomes included stool output, length of hospital and ICU stay, and 28-day mortality. The trial was conducted at the Emergency Intensive Care Unit of Ruijin Hospital between April 2026 and July 2026.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 8 Sept 2026
- Start date
- 1 Apr 2026
- Primary completion date
- 5 Jul 2026
- Lead sponsor
- Shanghai Jiao Tong University School of Medicine
- Diseases
- High blood pressure
- NCT number
- NCT07816900
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 1 Apr 2026 to the primary completion date, 5 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Urinary tract infection or prior bladder surgery (precluding bladder manometry)
Other illness
- Advanced malignancy (pancreatic, hepatobiliary, or gastrointestinal)
- Severe chronic organ failure
- Autoimmune disease or immunosuppression
- Intra-abdominal hemorrhage
- Allergic constitution or known allergy to study medication
- Psychiatric illness
Age
- Age \<18 or \>80 years
Other
- Pregnancy or lactation
Who the study is looking for
- Severe acute pancreatitis diagnosed according to the revised Atlanta classification
- Age 18-80 years
- Disease onset within 72 h
- Intra-abdominal hypertension (IAP \>= 12 mmHg) within 24 h of admission
- Written informed consent obtained
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Emergency Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.