NCT07818226Not yet recruiting
Effects of GLP-1 Receptor Agonists on Saliva and Oral Health
Prospective Evaluation of the Effects of GLP-1 Receptor Agonists on Salivary Physicochemical Parameters, Antimicrobial Peptide Levels, and Oral Health
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
This study aims to evaluate the effects of GLP-1 receptor agonists (GLP-1RA) on salivary parameters and oral health in individuals who will use this medication for the first time due to a diagnosis of Type 2 diabetes and/or obesity. The research will be conducted with a longitudinal design including a total of 50 participants. Clinical examinations and saliva analyses will be performed at baseline (month 0), month 3, and month 6. The study will evaluate stimulated and unstimulated salivary flow rates, pH, and buffering capacity, as well as analyze antimicrobial peptide levels (sIgA and beta-defensin-3) and total protein. Participants' oral hygiene and caries activity will be measured using the Silness and Löe Plaque Index (PI), DMFT, and ICDAS-II indices. Additionally, dietary habits and subjective dry mouth symptoms will be monitored through questionnaires. The obtained data will be statistically analyzed by controlling for potential confounding factors such as HbA1c, BMI, CRP, and HOMA index.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 2 Sept 2026
- Start date
- 16 Oct 2026
- Primary completion date
- 16 Jul 2027
- Lead sponsor
- Kırıkkale University
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT07818226
What you commit to
- Study type: Observational
- Planned participants: 50
- From 16 Oct 2026 to the primary completion date, 16 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of antibiotic or antifungal medications within the last 3 months.
Other illness
- Presence of Sjögren's syndrome or known salivary gland disease.
- History of radiation therapy to the head and neck region.
- Presence of other severe systemic diseases or use of medications that affect salivary flow.
Other
- Pregnancy, lactation, or active orthodontic treatment.
Who the study is looking for
- Diagnosed with Type 2 Diabetes Mellitus and/or Obesity.
- Newly prescribed a GLP-1 receptor agonist and naive to GLP-1 receptor agonist therapy.
- Aged 18 to 65 years
- Willing to provide saliva samples and complete study questionnaires.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kirikkale University Faculty of Dentistry Coordinator of this site? Confirm its status | Kirikkale | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.