NCT07818772Recruiting
7T Imaging Pilot-study in Patients With Motor Neuron Disease to Find Non-Invasive Disease Imaging Biomarkers
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
Motor Neuron Disease (MND) is a neurodegenerative disorder, which causes progressive loss of nerve cells controlling the muscles responsible for movement, speech, swallowing and breathing. MND is not actually a single disease, but a range of diseases; some more serious with patients dying within a year, and some less severe cases with a life expectancy of several years. It is often difficult and can take a long time to get a diagnosis of MND, by which time patients are often already very unwell. The aim of this research study is to improve the diagnosis of MND and make it faster. The investigators plan to achieve this goal by using advanced Magnetic Resonance Imaging (MRI) to develop new diagnostic tests for MND. The investigators will use a scanner with a very strong magnetic field of 7 tesla (7T), which provides images of the brain with increased detail compared to standard MRI scanners, which use magnetic field strengths of 1.5T or 3T. The investigators will use the advanced capability of 7T MRI to identify so-called imaging biomarkers, which are features of the scans that are specific to a particular disease, in this case MND and its different subtypes. This is a pilot study with a relatively small number of patients. The preliminary findings from this research will be used to design larger follow-on studies aiming to establish a fast and specific diagnosis for patients living with MND. This would allow patients to enter suitable trials faster and would help patients to receive more tailored treatment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 8 Jul 2026
- Start date
- 13 Apr 2026
- Primary completion date
- 30 Nov 2026
- Lead sponsor
- NHS Greater Glasgow and Clyde
- Diseases
- ALS (motor neurone disease)
- NCT number
- NCT07818772
What you commit to
- Study type: Observational
- Planned participants: 30
- From 13 Apr 2026 to the primary completion date, 30 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- active implants,
- post-surgical brain implants and metal ware
- Known major other confounding neurological disease or previous brain surgery
Other illness
- Respiratory failure
- Significant cognitive impairment, including loss of capacity secondary to fronto-temporal dementia
Other
- Contraindications to 7T MRI;
- tattoos in head and neck area
- Pregnancy
- Unable to comfortably or safely lie flat in an MRI scanner
- Unable to speak or understand any English (not complying with local 7T MRI safety SOPs)
- Unlikely to be able to lie still for the duration of the scan.
Who the study is looking for
- Male or non-pregnant female patients, ≥18 years of age
- Able to give informed consent
- Patients diagnosed as definite or probable motor neuron disease (El Escorial Criteria)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| ICE Building Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.