NCT07820384Not yet recruiting
The Effect of Time-Restricted Eating in 24-hour Metabolic Homeostasis and Diurnal Rhythm
Source: ClinicalTrials.gov · Last updated 15 Sept 2026
Brief summary (registry, in English)
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no food intake during the rest of the day. In animals, TRE improves metabolic function without caloric restriction. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. This study is a randomized controlled trial in people with obesity and prediabetes/insulin resistance. The overall goal of the study is to determine the effect of 9 h TRE for 12 weeks on key metabolic outcomes that are risk factors for cardiovascular disease (CVD): The goal of this study is to answer the following questions: 1) 24-hour metabolic homeostasis 2) 24h diurnal rhythm and appetite regulation.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 26 (estimated)
- First submitted
- 7 Jul 2026
- Start date
- 15 Sept 2026
- Primary completion date
- 1 Mar 2031
- Lead sponsor
- Cambridge University Hospitals NHS Foundation Trust
- Diseases
- Obesity
- NCT number
- NCT07820384
What you commit to
- Study type: Interventional
- Planned participants: 26
- From 15 Sept 2026 to the primary completion date, 1 Mar 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- use of medications that affect the study outcome measures or increase the risk of study procedures and that cannot be temporarily discontinued (e.g., steroids, alpha- or beta-adrenergic blockers or agonists, etc.)
- smoking and illegal drug use
- gastrointestinal or bariatric surgery (except cholecystectomy and appendectomy)
Other illness
- type 1 or 2 diabetes
- sleep disorder (individuals with well-controlled sleep apnoea)
- eating disorder
- cancer in last 5 years
- conditions that render subject unable to complete all testing procedures (including individuals with known allergies or contraindications to the medications used in this study)
Other
- shift worker
- fasting \>12 h/day more than once a week
- vegan
- \> once a week no food intake after \~1800 h
- habitually waking up before \~0400 h and sleeping before \~2100 h
- unstable weight (\>5% change the last 2 months)
- pregnant or lactating
- unable to grant voluntary informed consent or comply with the study instructions
- individuals with electromedical devices
- prisoners
- alcohol abuse
Who the study is looking for
- willing and able to give informed consent for participation in the study
- aged 35-75 years
- men and women
- body mass index 27-45 kg/m2
- fasting plasma glucose 5.6-6.9 mmol/L, or 2h OGTT plasma glucose 7.8-11.1 mmol/L or haemoglobin A1C 39-46 mmol/mol, homeostasis model assessment-insulin resistance (HOMA-IR) score ≥2.73
- self-reported habitual eating period ≥ 13 h per day
Age in the registry: 35 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cambridge Clinical Research Centre Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.