NCT07822711Recruiting
Effects of Different Stiffness Settings During Robotic Isokinetic Training in Children With SMA
Effects of Different Stiffness Settings on Isokinetic Quadriceps Training in Children With Spinal Muscular Atrophy: A Randomized Within-Participant, Contralateral-Limb-Controlled Trial
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
This randomized, within-participant, contralateral-limb-controlled clinical trial will compare individually optimized compliant and rigid stiffness settings of a portable isokinetic knee training robot in children with spinal muscular atrophy. At least 13 children aged 6 to 12 years will be enrolled. For each participant, one leg will be randomly assigned to the compliant setting and the contralateral leg to the rigid setting using sequentially numbered, opaque, sealed envelopes. Both legs will receive the same training volume, number of repetitions, and angular velocity for up to 8 weeks. The primary outcome is the between-setting difference in the change from baseline in peak isokinetic knee-extension torque. Secondary outcomes include knee-extension range of motion, quadriceps cross-sectional area on magnetic resonance imaging, femoral nerve conduction measures, and sit-to-stand performance. Knee pain, suprapatellar skin temperature, fatigue, and other adverse events will be monitored throughout the study.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 13 (estimated)
- First submitted
- 13 Sept 2026
- Start date
- 22 Oct 2026
- Primary completion date
- 15 Jan 2027
- Lead sponsor
- Peking University Third Hospital
- Diseases
- Spinal muscular atrophy
- NCT number
- NCT07822711
What you commit to
- Study type: Interventional
- Planned participants: 13
- From 22 Oct 2026 to the primary completion date, 15 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any other major disease or medical condition that, in the investigator's judgment, would interfere with safe participation or interpretation of the study results.
Age
- Blood pressure above the 95th percentile for age, sex, and height, as assessed by a clinician.
Other
- The legal guardian declines to provide written informed consent, or the participant is unable to complete the study procedures.
- Unable to undergo magnetic resonance imaging or electromyography and nerve conduction testing.
- Lacks the cognitive capacity to understand or comply with the requirements of study participation.
Who the study is looking for
- Age 6 to 12 years.
- Diagnosis of spinal muscular atrophy.
- Able to maintain an independent seated position.
- If receiving disease-modifying treatment, including nusinersen or risdiplam, the participant must have received a stable dose for at least 6 months before enrollment and must not change the treatment regimen during the study.
Age in the registry: 6 years to 12 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Peking University Third Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.