NCT07822932Recruiting
Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy
Mechanistic Modulation of HIV-Associated Peripheral Neuropathy in Older Adults Via Auricular Vagus Nerve Stimulation
Source: ClinicalTrials.gov · Last updated 6 Oct 2026
Brief summary (registry, in English)
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in heart function and pain signals. The goal is to learn how future treatments for nerve pain may be improved.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- First submitted
- 10 Sept 2026
- Start date
- Nov 2026
- Primary completion date
- 30 Aug 2028
- Lead sponsor
- University of Miami
- Diseases
- HIV
- NCT number
- NCT07822932
What you commit to
- Study type: Interventional
- Planned participants: 70
- From Nov 2026 to the primary completion date, 30 Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Implanted electronic or magnetic devices (e.g., pacemaker, cochlear implants, medication pumps, and other implanted neurostimulation systems)
- Recent ear trauma or metal implants in the head
- History of epilepsy, unprovoked seizure, stroke, brain tumor, significant traumatic brain injury, prior intracranial surgery, or other neurological condition associated with increased seizure risk
- Ferromagnetic or non-MRI-compatible metal in the head, neck, eye, or cranial region, including aneurysm clips, retained metal fragments, bullets, shrapnel, or other metallic implants not demonstrated to be TMS-compatible.
Other illness
- Unstable cardiac disease
- Head or neck cancer or metastases
- Active or uncontrolled comorbidities that independently cause neuropathy (e.g., recent chemotherapy, uncontrolled diabetes with documented neuropathic complications)
- Clinical evidence of non-HIV neuropathy (e.g., neuropathic symptoms predating HIV diagnosis, uncontrolled diabetes)
- Known allergy to tape/adhesive
Other
- Pregnancy or actively breast feeding
Who the study is looking for
- Established HIV infection
- Glove/stocking dysesthesias lasting for ≥3 months
- HIV-associated peripheral neuropathy (HIV-PN) related symptoms ≥4 (on a scale of 0-10) within the last week
- Stable medical care (i.e., no changes in Antiretroviral Therapy or pain medication within 2 months of enrollment)
- Able to read the consent form, demonstrate understanding of study procedures and requirements, and independently provide written informed consent
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Christine E Lynn Rehabilitation Center Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.