NCT07823777Not yet recruiting
Appendectomy as an Adjunct Procedure in Endometriosis Surgery
Appendectomy as an Adjunct Procedure in Endometriosis Surgery (AppEND)
Source: ClinicalTrials.gov · Last updated 16 Sept 2026
Brief summary (registry, in English)
This study addresses a common but unresolved clinical decision in endometriosis surgery: whether to perform an adjunct appendectomy. Currently, this decision is often based on individual surgeon judgement or institutional practice rather than robust evidence. This randomized controlled study aims to determine if removing a normal appearing appendix at the time of endometriosis surgery impacts post-operative recurrence of pelvic pain and endometriotic lesions at 12 months. Secondary outcomes include pathology of the appendix and complication rate of the procedure. Participants will be randomized to appendectomy or no appendectomy at the time of their planned endometriosis surgery. The study also includes an observational cohort that participants may opt to join if they do not wish to be randomized. Data are expected to guide surgical decision-making and contribute to the development of standardized surgical guidelines.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 240 (estimated)
- First submitted
- 18 Feb 2026
- Start date
- Apr 2027
- Primary completion date
- Apr 2028
- Lead sponsor
- Mount Sinai Hospital, Canada
- Diseases
- Endometriosis
- NCT number
- NCT07823777
What you commit to
- Study type: Interventional
- Planned participants: 240
- From Apr 2027 to the primary completion date, Apr 2028
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- No endometriosis seen at the time of surgery
- Previous appendectomy
Other
- Abnormal appearing appendix on imaging or intraoperatively
- Menopausal
Who the study is looking for
- Age 18-50 years
- Endometriosis diagnosis based on imaging or prior surgical findings
- Baseline pain above 3 on the Numerical Rating Scale (NRS)
- Undergoing surgical excision of endometriosis only, with at least one remaining ovary
Age in the registry: 18 years to 50 years · Sex: Female · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.