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NCT07823777Not yet recruiting

Appendectomy as an Adjunct Procedure in Endometriosis Surgery

Appendectomy as an Adjunct Procedure in Endometriosis Surgery (AppEND)

Source: ClinicalTrials.gov · Last updated 16 Sept 2026

Brief summary (registry, in English)

This study addresses a common but unresolved clinical decision in endometriosis surgery: whether to perform an adjunct appendectomy. Currently, this decision is often based on individual surgeon judgement or institutional practice rather than robust evidence. This randomized controlled study aims to determine if removing a normal appearing appendix at the time of endometriosis surgery impacts post-operative recurrence of pelvic pain and endometriotic lesions at 12 months. Secondary outcomes include pathology of the appendix and complication rate of the procedure. Participants will be randomized to appendectomy or no appendectomy at the time of their planned endometriosis surgery. The study also includes an observational cohort that participants may opt to join if they do not wish to be randomized. Data are expected to guide surgical decision-making and contribute to the development of standardized surgical guidelines.

Status (registry)
Not yet recruiting
Study type
Interventional
Enrollment
240 (estimated)
First submitted
18 Feb 2026
Start date
Apr 2027
Primary completion date
Apr 2028
Lead sponsor
Mount Sinai Hospital, Canada
NCT number
NCT07823777

What you commit to

  • Study type: Interventional
  • Planned participants: 240
  • From Apr 2027 to the primary completion date, Apr 2028
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • No endometriosis seen at the time of surgery
  • Previous appendectomy

Other

  • Abnormal appearing appendix on imaging or intraoperatively
  • Menopausal

Who the study is looking for

  • Age 18-50 years
  • Endometriosis diagnosis based on imaging or prior surgical findings
  • Baseline pain above 3 on the Numerical Rating Scale (NRS)
  • Undergoing surgical excision of endometriosis only, with at least one remaining ovary

Age in the registry: 18 years to 50 years · Sex: Female · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.