NCT07825649Not yet recruiting
Modelization of Early Endometrial-trophoblast Molecular Interaction
Source: ClinicalTrials.gov · Last updated 17 Sept 2026
Brief summary (registry, in English)
Despite significant advances in assisted reproductive technology, only 25% of in vitro fertilization (IVF) embryo transfers result in pregnancy, largely due to implantation failure. Preeclampsia complicates 2 to 5% of pregnancies, causes 76,000 maternal deaths worldwide each year, and is one of the leading causes of extreme prematurity (20% of premature births occurring before 32 weeks of gestation). The MEETMI project aims to characterize, in the laboratory, the early endometrium-trophoblast molecular interactions that determine the initial stages of human implantation and placentation. As part of routine care, patients will undergo a diagnostic hysteroscopy during which a endometrial biopsy may be performed. If the patient consents to participate in the study, an additional extended endometrial biopsy will be collected for research purposes.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 500 (estimated)
- First submitted
- 25 Mar 2026
- Start date
- 1 Oct 2026
- Primary completion date
- 1 May 2036
- Lead sponsor
- Centre Hospitalier Intercommunal Creteil
- NCT number
- NCT07825649
What you commit to
- Study type: Interventional
- Planned participants: 500
- From 1 Oct 2026 to the primary completion date, 1 May 2036
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patient who is HIV- or HCV-positive, regardless of viral load
- Patient whose medical history requires medication that may interfere with trophoblast biology (immunomodulators in cases of autoimmune diseases, anti-rejection drugs in transplant patients)
- Known genetic disorder in the patient
Age
- Age \< 18 or \> 50
Other
- Current pregnancy
- Patient refusal
- Woman under court-ordered protection
- Not enrolled in the general social security system
- Unable to understand and sign the consent form
Who the study is looking for
- Medical indication for a diagnostic hysteroscopy between the ages of 18 and 50
- Comprehensive information provided prior to the hysteroscopy
- Informed consent signed by the patient
Age in the registry: 18 years to 50 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chi Creteil Coordinator of this site? Confirm its status | Créteil | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.