NCT07827963Not yet recruiting
VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism
Source: ClinicalTrials.gov · Last updated 18 Sept 2026
Brief summary (registry, in English)
VISMEMO-PD is an observational pilot study aimed at investigating visuospatial memory in reaching space and topographical memory in navigational space in patients with Parkinson's disease and Parkinsonism. The protocol is based on the hypothesis that topographical memory may deteriorate before visuospatial memory, suggesting that navigational memory impairment could represent an early indicator of disease progression. The study will include 80 participants stratified into four groups: patients with mild Parkinson's disease, patients with moderate-advanced Parkinson's disease, patients with Parkinsonism, and healthy participants. Visuospatial memory will be assessed using the Corsi Block-tapping Test, while topographical memory will be assessed using the Walking Corsi Test. Walking motor patterns will be recorded using wearable inertial sensors from the MOVIT system, and visual exploration strategies will be assessed using a wearable Pupil Labs eye-tracking system. The integration of cognitive, motor, and eye-tracking measures may support the identification of early neuropsychological markers and the development of tailored neurorehabilitation pathways for individuals with Parkinson's disease and Parkinsonism.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 14 Sept 2026
- Start date
- Sept 2026
- Primary completion date
- Oct 2028
- Lead sponsor
- IRCCS San Raffaele Roma
- Diseases
- Parkinson disease
- NCT number
- NCT07827963
What you commit to
- Study type: Observational
- Planned participants: 80
- From Sept 2026 to the primary completion date, Oct 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Diagnosis of neurological disorders other than Multiple System Atrophy (MSA) and Parkinson's disease;
- Depressive disorders or Beck Depression Inventory-II (BDI-II) score \> 20;
- Diagnosis of neurological disorders;
- Depressive disorders or Beck Depression Inventory-II (BDI-II) score \> 20;
- Musculoskeletal disorders that could impair gait performance.
Age
- Musculoskeletal disorders that could impair gait performance.
- The study will enroll 20 healthy subjects, matched by age and sex with patients affected by Parkinson's disease (PD) and atypical parkinsonism who will be recruited into the study.
- The same inclusion criteria will be applied to both groups of patients with Multiple System Atrophy (MSA) and Parkinson's disease.
- The exclusion criteria will be:
Who the study is looking for
- Male and female subjects aged between 35 and 80 years;
- Diagnosis of Parkinson's disease according to the United Kingdom (UK) Parkinson's Disease Society Brain Bank criteria;
- Diagnosis of primary atypical parkinsonism MSA-P, according to the Second Consensus Statement on the Diagnosis of Multiple System Atrophy;
- Diagnosis of primary atypical parkinsonism PSP-P, according to the Movement Disorder Society criteria for Progressive Supranuclear Palsy;
- Modified Hoehn and Yahr stage between 1 and 3 during the "ON" phase (Hoehn and Yahr, 1967);
- Cognitive screening with the Montreal Cognitive Assessment (MoCA) score \> 17;
- Mini-Mental State Examination (MMSE) score ≥ 24 (Folstein et al., 1975);
- Ability to walk independently for 10 meters without assistive devices;
- Ability to understand and sign the informed consent form;
- Ability to comply with study procedures.
Age in the registry: 35 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS San Raffaele Cassino - CTC Via G. di Biasio, 1 Coordinator of this site? Confirm its status | Cassino | Italy | Unknown status |
| University of Roma La Sapienza Department of Psychology University of Rome Coordinator of this site? Confirm its status | Roma | Italy | Unknown status |
| University of Roma La Sapienza Department of Psychology University of Rome 00185, Rome Coordinator of this site? Confirm its status | Roma | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.