NCT07829055Enrolling by invitation
Effects of Mental Tasks on Breathing Patterns in Adults Using Chronic Opioids vs Non-opioid Users.
Control of Ventilation During Wakefulness in Opioid vs. Non-opioid Patients
Source: ClinicalTrials.gov · Last updated 18 Sept 2026
Brief summary (registry, in English)
The goal of this observational study is to find out if using your brain for a mental task changes how you breathe. Researchers want to compare three groups of adults: people who take opioid pain medicine every day, people with sleep apnea, and healthy people with neither condition. The main questions this study aims to answer are: * Does breathing change differently during mental tasks in people who take opioids, people with sleep apnea, and healthy controls? * Is the connection between brain activity and breathing disrupted more in people who use chronic opioids or have OSA, compared with healthy controls, during periods of mental effort? Researchers will compare the three groups to see if opioid use or sleep apnea makes breathing less steady, or weakens the link between the brain and breathing, when a person is concentrating on a task. Participants will visit the UC San Diego Sleep Laboratory one time. During the visit, they will: * Answer questions about sleep, opioid use, and sleep apnea risk. * Have sensors placed on their skin and scalp to measure brain waves, breathing, and oxygen levels. This is the same kind of equipment used in a regular sleep study, and it does not hurt. * Sit quietly and rest while their breathing and brain waves are recorded. * Do a series of short mental tasks on a computer, tablet, or paper, testing things like memory, attention, and thinking speed, while their breathing and brain waves continue to be recorded. No medicine or treatment will be given during the study, and no blood or other samples will be collected. This study only involves watching and measuring, not testing any treatment.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 14 Sept 2026
- Start date
- 16 Sept 2026
- Primary completion date
- Mar 2027
- Lead sponsor
- University of California, San Diego
- NCT number
- NCT07829055
What you commit to
- Study type: Observational
- Planned participants: 40
- From 16 Sept 2026 to the primary completion date, Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Significant comorbidities of other organ systems (e.g., chronic kidney disease, CHF/active cardiac symptoms, cirrhosis, severe lung disease)
- Diseases affecting respiratory muscles or breathing control (neuromuscular, neurodegenerative, congenital)
- Psychiatric disease other than controlled mood disorders
Other
- Prisoners
- Pregnancy
- BMI \<20 or \>35
- Unable/unwilling to give informed consent or comply with study procedures
Who the study is looking for
- All participants
- Able to provide informed consent
- Able to communicate in English, see/hear task stimuli (with usual corrective devices), follow multistep instructions, and complete a brief cognitive-task practice example
- Opioid group
- Daily prescribed opioid use, under medical supervision, for chronic non-cancer pain, for ≥3 months
- Prescribed dose ≥20 MME/day (no upper limit)
- Stable dose for ≥2 weeks
- OSA group
- \- Diagnosed OSA with AHI ≥15 events/hour (documented on a prior clinical sleep study)
- Healthy control group
- No history of chronic prescribed opioid use
- No known history/diagnosis of OSA
- If a prior sleep study exists, AHI must be \<10 events/hour within the past 3 years
Age in the registry: 45 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of California San Diego Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.