NCT07830719RecruitingPhase 2
A clinical trial to learn more about the effects of YMI024 in people with coronary artery disease
A Phase 2b, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-finding study of YMI024 to assess efficacy in reducing inflammatory markers, safety, and tolerability in adults with stable coronary artery disease and elevated hsCRP
Source: EU CTIS (euclinicaltrials.eu) · Last updated 5 Aug 2026
Brief summary (registry, in English)
To evaluate the dose-response relationship of YMI024 compared with placebo in reducing inflammatory markers in adults with stable CAD and elevated hsCRP ≥2 mg/L
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 43 (estimated)
- First submitted
- 16 Jun 2026
- Start date
- 29 Sept 2026
- Lead sponsor
- Novartis Pharma AG
- EU CT number
- 2026-525974-21-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 43
- 14 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants who have certain heart problems, like a heart attack within 30 days before entering the trial
Other illness
- Participants who have undergone open heart surgery in the past 6 months
- Participants who have an autoimmune disease like rheumatoid arthritis or Crohn’s disease or ulcerative colitis and are taking certain therapies to treat, or if they have certain chronic infections such as hepatitis B or C
Who the study is looking for
- Signed informed consent must be obtained prior to any study specific procedures, and participant able to understand and comply with study requirements.
- Male and female participants aged between 18-80 years (inclusive) at Screening.
- Confirmed diagnosis of CAD
- Participants have CRP levels more than ≥2 mg/L, which is a sign of increased inflammation
- Participant may be receiving standard treatment for high blood pressure, high cholesterol, diabetes, kidney and heart problems
- Participant may have ongoing kidney disease or heart failure
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Velocity Clinical Research Germany GmbH Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| Charite Universitaetsmedizin Berlin KöR Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| Klinisches Forschungszentrum Dr. Hagemann Coordinator of this site? Confirm its status | Essen | Germany | Recruiting |
| Medical Center- University of Freiburg Coordinator of this site? Confirm its status | Freiburg im Breisgau | Germany | Recruiting |
| Hausarztzentrum Butendorf Coordinator of this site? Confirm its status | Gladbeck | Germany | Recruiting |
| Kardiopraxis Schirmer Coordinator of this site? Confirm its status | Kaiserslautern | Germany | Recruiting |
| Klinikum Konstanz GmbH Coordinator of this site? Confirm its status | Konstanz | Germany | Recruiting |
| Universitaetsklinikum Leipzig Aor Coordinator of this site? Confirm its status | Leipzig | Germany | Recruiting |
| Gemeinschaftspraxis Dr. Jens Biesenbaum/Dr. Uwe Gerbaulet Coordinator of this site? Confirm its status | Loehne | Germany | Recruiting |
| Haus der Gesundheit Coordinator of this site? Confirm its status | Ludwigshafen | Germany | Recruiting |
| ze:ro Praxen MVZ fuer Nierenerkrankungen und Bluthochdruck GmbH Mannheim Coordinator of this site? Confirm its status | Mannheim | Germany | Recruiting |
| Diabetologische Schwerpunktpraxis Pirna Hausärztliche Versorgung Coordinator of this site? Confirm its status | Pirna | Germany | Recruiting |
| Robert Bosch Gesellschaft fuer medizinische Forschung mbH Coordinator of this site? Confirm its status | Stuttgart | Germany | Recruiting |
| Cardiologicum Herzklinik Ulm MVZ GmbH Coordinator of this site? Confirm its status | Ulm | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.