NCT07831538Not yet recruiting
Digital Outreach for Heart Failure Adherence
Adherence Through Digital Health: Evaluating Randomized Engagement in Heart Failure
Source: ClinicalTrials.gov · Last updated 1 Oct 2026
Brief summary (registry, in English)
The goal of the ADHERE-HF study is to evaluate whether care-embedded, operationally delivered digital outreach improves medication refill, adherence, and clinical outcomes among adults with heart failure who are overdue for a refill of an eligible guideline-directed medical therapy (GDMT) medication. The main question it aims to answer is: Does digital outreach using interactive text messages or automated telephone calls increase short-term refill of overdue heart failure medications compared with usual care? The study will evaluate the effectiveness of a digital outreach strategy delivered through existing health system communication channels. Members who have opted in to pharmacy text messaging will receive interactive text messages, while those who have not opted in will receive an interactive automated telephone call. The comparison group will receive usual care with no additional outreach.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 13714 (estimated)
- First submitted
- 13 Sept 2026
- Start date
- 21 Sept 2026
- Primary completion date
- Mar 2027
- Lead sponsor
- Kaiser Permanente
- Diseases
- Heart failure
- NCT number
- NCT07831538
What you commit to
- Study type: Interventional
- Planned participants: 13714
- From 21 Sept 2026 to the primary completion date, Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving hospice or comfort-focused care
- Skilled nursing facility stay within prior 12 months
- Opted out of receiving pharmacy medication adherence outreach from Kaiser Permanente
Other illness
- Documented allergy or intolerance to all eligible GDMT medications for which the patient is overdue
- Other conditions that prevent outreach
Other
- No valid telephone number on file through which the patient could be reached by text message or automated telephone call
Who the study is looking for
- Age ≥18 years
- Active KPNC membership
- Heart failure diagnosis documented at least 6 months before the index date, with a documented EF
- Prescribed at least one eligible GDMT medication for ≥6 months:
- HFpEF (EF≥50%): ARNI (sacubitril/valsartan); MRA; SGLT2i
- HFrEF or HFmrEF (EF \<50%): ARNI (sacubitril/valsartan), ACEi, or ARB; Beta-blocker (bisoprolol, carvedilol, or sustained-release metoprolol succinate); MRA; SGLT2i
- At least one unfilled refill for an eligible GDMT medication that is 7-13 days overdue at index
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kaiser Permanente-Division of Research Coordinator of this site? Confirm its status | Pleasanton | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.