NCT07831603Not yet recruiting
Stearic Acid and Endothelial Function
Source: ClinicalTrials.gov · Last updated 4 Nov 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate the postprandial and long-term effects of dietary stearic acid on vascular function in overweight or obese adult males and females aged 40-70 years. The main questions it aims to answer are: 1. Does consuming a high stearic acid-rich meal improve postprandial vascular function compared to a high oleic acid-rich meal? 2. Does a 14-day stearic acid-rich diet improve fasting vascular function compared to an oleic acid-rich diet? 3. Does a 14-day stearic acid-rich diet reduce the impairment of postprandial vascular function following a high palmitic-acid challenge meal? Participants will: * Complete screening questionnaires, a 3-day food log, body composition measurements, and fasting blood and urine tests. * Consume a provided, 14-day controlled diet high in palmitic acid while avoiding outside food and beverages other than water. * Be randomly assigned to consume a provided 14-day diet high in either stearic acid (cocoa butter blend) or oleic acid (plant oil blend). * Attend two 5-hour testing visits at the clinic after overnight fasting. * Undergo intravenous (IV) catheter placement for repeated blood sampling and non-invasive vascular health assessments (ultrasound artery checks and pulse measurements). * Consume assigned high-fat test meals within 15 minutes and undergo hourly vascular and blood assessments over a 4-hour period.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 15 Sept 2026
- Start date
- 1 Dec 2026
- Primary completion date
- Aug 2027
- Lead sponsor
- Florida State University
- Diseases
- Obesity
- NCT number
- NCT07831603
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Dec 2026 to the primary completion date, Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current or recent use of weight loss medications
- Current or recent use of tobacco, nicotine, or illicit drugs
Other illness
- Current diagnosis or history of diabetes, renal disease, liver disease, gallbladder disease, cholecystectomy, pancreatic disease, cancer, overt cardiovascular disease, or a major cardiovascular event (e.g., heart attack or stroke)
- History of bariatric surgery
Lab values
- Current or recent use of glucose- or lipid-lowering drugs
- Fasting LDL cholesterol ≥ 190 mg/dL or fasting plasma total cholesterol \> 7.8 mmol/L (302 mg/dL), or fasting plasma TAG \> 3 mmol/L (267 mg/dL)
Other
- Significant change in bodyweight of ≥ 5% within the past 6 months
- Hysterectomy or ovarian removal (females)
- Pregnant or lactating
- Athlete
- Unwilling or unable to provide consent
- Unwilling or unable to consume study diet
Who the study is looking for
- Adults ages 40-70 years
- BMI 25.0-40.0 kg/m2
- Seated blood pressure \<130/80 mmHg
- Willing and able to attend laboratory visits
Age in the registry: 40 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Florida State University Coordinator of this site? Confirm its status | Tallahassee | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.