NCT07833813Not yet recruiting
Incretin Therapy and Exercise in Type 2 Diabetes
Effects of Incretin Memetics and Exercise on Gut-brain and Metabolic Health in Persons With Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 22 Sept 2026
Brief summary (registry, in English)
This study will examine changes in brain and physical health in adults with type 2 diabetes who are initiating incretin-mimetic therapy (e.g., Ozempic, Mounjaro), and determine whether adding structured exercise provides additional benefits. Participants will be randomized to receive incretin-mimetic therapy alone or incretin-mimetic therapy plus a structured exercise program for 24 weeks. If the participant is randomly assigned to the incretin-based therapy alone group, they will have the opportunity to complete the same structured exercise program after the 24-week study period is complete. Brain health will be assessed through cognitive performance, mental health, and brain-mediated appetite regulation. The study will also assess gut microbiota and motor-cortex neuroplasticity as potential factors associated with changes in brain health, as well as glucose regulation, body composition, physical function, and cardiorespiratory fitness. Assessments will be completed at baseline, 8 weeks, and 24 weeks. Findings will help determine how incretin-mimetic therapy and exercise can be integrated to support brain and physical health in adults with type 2 diabetes.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 110 (estimated)
- First submitted
- 16 Sept 2026
- Start date
- Sept 2026
- Primary completion date
- Sept 2028
- Lead sponsor
- University of Regina
- Diseases
- Type 2 diabetes
- NCT number
- NCT07833813
What you commit to
- Study type: Interventional
- Planned participants: 110
- From Sept 2026 to the primary completion date, Sept 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- current use of incretin-based therapy outside the study-defined enrollment window
Other illness
- any other medical condition or circumstance that, in the opinion of the research team, would interfere with safe participation or completion of study procedures
Other
- pregnant or planning to become pregnant during the study period
Who the study is looking for
- adults aged 18 years or older
- diagnosed with pre diabetes or type 2 diabetes
- prescribed incretin-based therapy (e.g., semaglutide or tirzepatide)
- able and willing to participate in the study assessments and, if randomized to the exercise group, the 24-week structured exercise program
- able to provide informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre for Kinesiology Coordinator of this site? Confirm its status | Regina | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.